{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:30:23Z","timestamp":1784100623730,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The relationship between dental caries and stroke remains inconclusive. The aim of this study is to investigate whether different severities of dental caries affect the risk of stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study was conducted using the 2000\u20132013 Taiwan National Health Insurance Database. We selected 23,662 patients with advanced\/severe dental caries and 23,662 patients with incipient\/moderate dental caries between 2000 and 2006. These patients were followed to the occurrence of stroke or to the end of the study in 2013. Hazard ratios (HRs) and 95% confidence intervals (CIs) derived from the Cox proportional hazards models were calculated to assess the association between severity of dental caries and the risk of stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The advanced\/severe dental caries group had a significantly higher risk of stroke compared with incipient\/moderate dental caries group (adjusted HR, 1.16; 95% CI, 1.03\u20131.31). Stratified analyses showed that advanced\/severe dental caries was positively associated with the risk of ischemic stroke in patients aged \u226540\u2009years and with the risk of hemorrhagic stroke in patients aged &lt;40\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is a severity\u2010dependent association between dental caries and stroke in an Asian population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14756","type":"journal-article","created":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T02:49:38Z","timestamp":1697856578000},"page":"3413-3421","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between severity of dental caries and the risk of 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