{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T05:25:22Z","timestamp":1778217922374,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T00:00:00Z","timestamp":1697155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The present study evaluated the oral tissue expression of micro\u2010RNA (miRNAs) linked to the potential malignant evolution of oral lichen planus (OLP). Furthermore, the correlation between OLP severity and miRNAs expression was assessed, and possible predictors of miRNAs in OLP patients were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The present study enrolled 41 patients with OLP (median age 58\u2009years) and 42 healthy controls (median age 59\u2009years). In each patient, miRNA levels (miR\u20107a\u20103p,\u20107a2\u20103p,\u20107a\u20105p,\u201021\u20103p,\u201021\u20105p,\u2010100\u20103p,\u2010100\u20105p,\u2010125b\u20102\u20103p,\u2010125b\u20105p,\u2010200b\u20103p,\u2010200b\u20105p) were assessed and analyzed through reverse transcription polymerase chain reaction. Clinical parameters and the eventual presence of OLP symptoms, signs, and disease severity scores in each patient were reported using an anamnestic questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In comparison with healthy controls, OLP patients showed significantly higher miR\u20107a\u20103p,\u20107a\u20102\u20103p,\u201021\u20103p, miR\u201021\u20105p and miR\u2010100\u20105p levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) and significantly lower miR\u2010125b\u20102\u20103p,\u2010125b\u20105p,\u2010200b\u20103p, and \u2010200b\u20105p levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Furthermore, OLP symptoms and signs and disease severity scores were significantly correlated and were also predictors of all analyzed miRNAs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In comparison with healthy subjects, OLP patients exhibited unbalanced oral miRNAs expression linked to the risk of potential malignant evolution of OLP. Furthermore, some miRNAs were correlated with OLP extent and were significant predictors of OLP symptoms, signs, and disease severity scores.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14758","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T01:14:35Z","timestamp":1697246075000},"page":"2918-2928","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Analysis of oral lichen planus severity on micro\u2010\n                    <scp>RNA<\/scp>\n                    linked with malignant transformation risks"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6717-8899","authenticated-orcid":false,"given":"Alessandro","family":"Polizzi","sequence":"first","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties, Unit of Periodontology, School of Dentistry University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Santonocito","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties, Unit of Periodontology, School of Dentistry University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfio","family":"Distefano","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco","family":"De\u00a0Pasquale","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties, Unit of Periodontology, School of Dentistry University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Alibrandi","sequence":"additional","affiliation":[{"name":"Department of Economics, Unit of Statistical and Mathematical Sciences University of Messina  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amer M.","family":"Alanazi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Biotechnology Laboratory, Department of Pharmaceutical Chemistry, College of Pharmacy King Saud University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Li\u00a0Volti","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Biotechnological Sciences University of Catania  Catania Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-6992","authenticated-orcid":false,"given":"Gaetano","family":"Isola","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties, Unit of Periodontology, School of Dentistry University of Catania  Catania 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