{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:49:37Z","timestamp":1781714977174,"version":"3.54.5"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Connexin43 (Cx43) is involved in the inflammation of many tissue types. Dental caries is infectious disease resulting from mineralized tissue dissolution by a specific bacterial population, causing pulp inflammation. However, Cx43's role in dental pulp remains unclear. Here, we investigated the function of Cx43 during pulp inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>We constructed a dentin injury model in Sprague\u2013Dawley rats to investigate changes in Cx43 expression during pulp inflammation. Cx43 was inhibited in human dental pulp cells (hDPCs) that had been stimulated with lipopolysaccharide (LPS) to investigate the effect of Cx43 on inflammatory response. Promotion of TLR4\u2010NF\u2010\u03baB pathway activity and special Cx43 channel inhibitors were used to clarify the function of Cx43 in hDPCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dentin injury led to low\u2010level inflammation in dental pulp. Following dentin injury, Cx43 expression initially decreased before gradually recovering to normal levels. Cx43 inhibition reduced LPS\u2010induced expression of inflammatory cytokines and NF\u2010\u03baB pathway activity. Promotion of NF\u2010\u03baB pathway activity counteracted the effect of Cx43 in hDPCs. Furthermore, inhibition of Cx43 hemichannels reduced LPS\u2010induced inflammatory cytokine expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cx43 is involved in inflammation of dental pulp, while its inhibition reduced LPS\u2010induced inflammation in hDPCs through NF\u2010\u03baB pathway via blockage of hemichannels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14767","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:13:42Z","timestamp":1697058822000},"page":"3239-3249","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Connexin43 reduces\n                    <scp>LPS<\/scp>\n                    \u2010induced inflammation in\n                    <scp>hDPCs<\/scp>\n                    through\n                    <scp>TLR4\u2010NF\u2010\u03baB<\/scp>\n                    pathway via hemichannels"],"prefix":"10.1111","volume":"30","author":[{"given":"Ping","family":"Long","sequence":"first","affiliation":[{"name":"Department of Operative Dentistry and Endodontics, School of Stomatology Southwest Medical University  Lu Zhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Endodontics, School of Stomatology Southwest Medical University  Lu Zhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cancan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Endodontics, School of Stomatology Southwest Medical University  Lu Zhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Endodontics, School of Stomatology Southwest Medical University  Lu Zhou China"},{"name":"Department of Stomatology Chengdu Children's Specialized Hospital  Cheng Du China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanpei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Endodontics, School of Stomatology Southwest Medical University  Lu Zhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Endodontics, School of Stomatology Southwest Medical University  Lu Zhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Endodontics, School of Stomatology Southwest Medical University  Lu Zhou 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