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Perioperative pain was predominantly evaluated in patients undergoing surgery for impacted molars, although some studies also included patients with other conditions such as oral submucous fibrosis, maxillary cancer, bony temporomandibular joint ankylosis, irreversible pulpitis, among others. Combined with dexmedetomidine, fentanyl produced enhanced analgesic effects. It demonstrated comparable efficacy when compared to nefopam and nalbuphine. Both intranasal and intravenous administration routes proved equally effective. In four RCTs, the transdermal fentanyl patch outperformed the control group, except in the clinical trial where it was compared to ropivacaine. The main adverse events associated with the use of fentanyl included nausea, vomiting, drowsiness, delirium, and respiratory depression; however, they were like those reported in the comparison groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While fentanyl demonstrated satisfactory perioperative analgesic efficacy, there were other alternatives that displayed better or comparable outcomes. Due to the risks and potential for misuse of fentanyl, these alternatives must be considered although adverse events were also reported.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.14773","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T05:24:15Z","timestamp":1697261055000},"page":"2807-2819","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Perioperative analgesic efficacy and adverse events of fentanyl in dentistry: A systematic review"],"prefix":"10.1111","volume":"30","author":[{"given":"Carlos M.","family":"Ardila","sequence":"first","affiliation":[{"name":"Universidad de Antioquia  Medell\u00edn Colombia"},{"name":"Biomedical Stomatology Research Group Universidad de Antioquia  Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo A.","family":"Jim\u00e9nez\u2010Arbel\u00e1ez","sequence":"additional","affiliation":[{"name":"Professor Instituci\u00f3n Universitaria Visi\u00f3n de Las Am\u00e9ricas  Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie Marcela","family":"Vivares\u2010Builes","sequence":"additional","affiliation":[{"name":"Professor Instituci\u00f3n Universitaria Visi\u00f3n de Las Am\u00e9ricas  Medell\u00edn Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.17245\/jdapm.2023.23.2.69"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc6789"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S140320"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.24875\/RIC.23000109"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41415\u2010019\u20100807\u20104"},{"issue":"2","key":"e_1_2_9_7_1","first-page":"151","article-title":"Acute oral pain intensity and pain threshold assessed by intensity matching to pain induced by electrical stimuli","volume":"17","author":"Alstergren P.","year":"2003","journal-title":"Journal of Orofacial Pain"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4334269"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina59050924"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.02.012"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278\u20102391(88)90449\u20101"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.17245\/jdapm.2019.19.1.55"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2008.03.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4677"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704515"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663\u2010009\u20100014\u2010y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975\u20105950.79211"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278\u20102391(88)90414\u20104"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000001284"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010270.pub2"},{"key":"e_1_2_9_21_1","first-page":"445","article-title":"Analgesic effects of morphine after PDL injection in endodontic patients","volume":"70","author":"Hargreaves K.","year":"1991","journal-title":"Journal of Dental Research"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197\u20102456(95)00134\u20104"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2017.281626"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.01.044"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(19)30128\u20108"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916\u2010019\u20100780\u20102"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15573"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/joacp.JOACP_405_20"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060514525351"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2018.05.042"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLE.0000000000000630"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0885\u20103924(01)00251\u20102"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.51731\/cjht..28"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.RVW.O.00055"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.3344\/kjp.2016.29.2.110"},{"key":"e_1_2_9_36_1","unstructured":"National Institute on Drug Abuse. 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