{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:08:49Z","timestamp":1793304529008,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Confirm that stem cells from human exfoliated deciduous teeth\u2010derived exosomes (SHED\u2010exos) can limit inflammation\u2010triggered epithelial cell apoptosis and explore the molecular mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      SHED\u2010exos were injected into the submandibular glands (SMGs) of non\u2010obese diabetic (NOD) mice, an animal model of Sj\u00f6gren's syndrome (SS). Cell death was evaluated by western blotting and terminal deoxynucleotidyl transferase\u2010mediated\n                      <jats:styled-content style=\"fixed-case\">dUTP<\/jats:styled-content>\n                      nick\u2010end labelling staining.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      SHED\u2010exos treatment promoted the saliva flow rates of NOD mice, accompanied by decreased cleaved caspase\u20103 levels and apoptotic cell numbers in SMGs. SHED\u2010exos inhibited autophagy, pyroptosis, NETosis, ferroptosis, necroptosis and oxeiptosis marker expression in SS\u2010damaged glands. Mechanistically, Kyoto Encyclopedia of Genes and Genomes analysis of exosomal miRNAs suggested that the rat sarcoma virus (RAS)\/mitogen\u2010activated protein kinase kinase (MEK)\/extracellular signal\u2010regulated kinase (ERK) pathway might play an important role. In\u00a0vivo, the expression of Kirsten RAS, Harvey RAS, MEK1\/2 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2010ERK1\/2 was upregulated in SMGs, and this change was blocked by SHED\u2010exos treatment. In\u00a0vitro, SHED\u2010exos suppressed\n                      <jats:italic>p<\/jats:italic>\n                      \u2010ERK1\/2 activation and increased cleaved caspase\u20103 and apoptotic cell numbers, which were induced by IFN\u2010\u03b3.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      SHED\u2010exos suppress epithelial cell death, which is responsible for promoting salivary secretion. SHED\u2010exos inhibited inflammation\u2010triggered epithelial cell apoptosis by suppressing\n                      <jats:italic>p<\/jats:italic>\n                      \u2010ERK1\/2 activation, which is involved in these effects.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14776","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T01:58:15Z","timestamp":1697594295000},"page":"3066-3080","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["<scp>SHED<\/scp>\n                    \u2010exos promote saliva secretion by suppressing\n                    <scp>\n                      <i>p\u2010<\/i>\n                      ERK1\n                    <\/scp>\n                    \/2\u2010mediated apoptosis in glandular cells"],"prefix":"10.1111","volume":"30","author":[{"given":"Wei\u2010Xia","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Periodontics Shanxi Medical University School and Hospital of Stomatology  Taiyuan Shanxi P.R. 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