{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:01:42Z","timestamp":1789448502885,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the frequency of oral squamous cell carcinoma (OSCC) associated or not with oral potentially malignant disorders (OPMD), and the epidemiological profile and traditional risk factors in Latin America.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A retrospective observational study was conducted in 17 Latin American centres. There were included cases of OSCC, analysing age, gender, OSCC and their association with previous OPMD. Clinicopathological variables were retrieved. The condition of sequential\u2010OSCC versus OSCC\u2010de novo (OSCC\u2010dn) was analysed concerning the aforementioned variables. Quantitative variables were analysed using Student's\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test, and qualitative variables with chi\u2010square.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 2705 OSCC were included with a mean age of 62.8\u2009years old. 55.8% were men. 53.75% of the patients were smokers and 38% were common drinkers. The lateral tongue border was the most affected site (24.65%). There were regional variations in OPMD, being leukoplakia the most frequent. Of the overall 2705 OSCC cases, 81.4% corresponded to OSCC\u2010dn, while s\u2010OSCC were 18.6%. Regarding lip vermillion SCC, 35.7% corresponded to de novo lip SCC and 64.3% were associated with previous OPMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Latin America, OSCC\u2010dn seems to be more frequent with regional variations of some clinical and histopathological features. Further prospective studies are needed to analyse this phenomenon.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14778","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T07:00:27Z","timestamp":1698217227000},"page":"2965-2984","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Oral squamous cell carcinomas and oral potentially malignant disorders: A Latin American study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-1444","authenticated-orcid":false,"given":"Gerardo","family":"Gilligan","sequence":"first","affiliation":[{"name":"Oral Medicine Department \u201cA\u201d, Facultad de Odontolog\u00eda Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5833-5546","authenticated-orcid":false,"given":"Ren\u00e9","family":"Panico","sequence":"additional","affiliation":[{"name":"Oral Medicine Department \u201cA\u201d, Facultad de Odontolog\u00eda Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0881-9614","authenticated-orcid":false,"given":"Jer\u00f3nimo","family":"Lazos","sequence":"additional","affiliation":[{"name":"Oral Medicine Department \u201cA\u201d, Facultad de Odontolog\u00eda Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0073-7291","authenticated-orcid":false,"given":"Rosana","family":"Morelatto","sequence":"additional","affiliation":[{"name":"Oral Medicine Department \u201cB\u201d, Facultad de Odontolog\u00eda Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1264-8969","authenticated-orcid":false,"given":"Paola","family":"Belardinelli","sequence":"additional","affiliation":[{"name":"Oral Medicine Department \u201cB\u201d, Facultad de Odontolog\u00eda Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9043-3931","authenticated-orcid":false,"given":"Maria Ines","family":"Criscuolo","sequence":"additional","affiliation":[{"name":"Oral Medicine Department \u201cB\u201d, Facultad de Odontolog\u00eda Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8668-185X","authenticated-orcid":false,"given":"Nicolas","family":"Bolesina","sequence":"additional","affiliation":[{"name":"Oral Medicine Department \u201cB\u201d, Facultad de Odontolog\u00eda Universidad Nacional de C\u00f3rdoba  C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5269-3254","authenticated-orcid":false,"given":"Ignacio","family":"Molina\u00a0\u00c1vila","sequence":"additional","affiliation":[{"name":"Hospital Se\u00f1or del Milagro  Salta Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8041-5657","authenticated-orcid":false,"given":"Juan\u00a0Martin","family":"Pimentel\u00a0Sol\u00e1","sequence":"additional","affiliation":[{"name":"Hospital Se\u00f1or del Milagro  Salta Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilce","family":"Rivarola","sequence":"additional","affiliation":[{"name":"Hospital Luis C. 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