{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:37:08Z","timestamp":1773794228402,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T00:00:00Z","timestamp":1697673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006181","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado da Bahia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate whether genes in the Wnt pathway, which have been previously associated with both oral clefts and oral squamous cell carcinoma, are also associated with oral potentially malignant disorders (leukoplakia, erythroplakia and lichen planus).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Case\u2013control study: Dataset consisted of clinical information linked to DNA samples from affected subjects diagnosed with oral potential malignant disorders and oral cancer and their matched controls. Individual samples, clinical history, and potential risk factors were obtained through the Dental Registry and DNA Repository project of the School of Dental Medicine, University of Pittsburgh. The rs1533767 (WNT11), rs9879992 (GSK3B), and rs3923087 (AXIN2) were tested. After genomic DNA had been extracted, genotyping was performed blindly to clinical diagnosis status. Representation of genotypes and alleles in affected subjects in comparison to the unaffected individuals was determined using PLINK. Additional analysis was performed to investigate associations between environmental (socioeconomic\/lifestyle) risk factors and the oral pathologies studied using STATA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two of the SNPs tested (rs9879992 in GSK3B and rs3923087 in AXIN2) were statistically, significantly associated with the pathologies studied (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039 and 0.038, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Single\u2010nucleotide polymorphisms in genes in the Wnt pathway were associated with oral potentially malignant disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14779","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T14:15:16Z","timestamp":1697724916000},"page":"2985-2990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Polymorphisms associated with oral clefts as potential markers for oral pre and malignant disorders"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9314-6970","authenticated-orcid":false,"given":"Adriana Mendon\u00e7a","family":"da Silva","sequence":"first","affiliation":[{"name":"Public Health PhD Graduate Program State University of Feira de Santana  Feira de Santana Brazil"},{"name":"Department of Oral and Craniofacial Sciences University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria Souza","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Health State University of Feira de Santana  Feira de Santana Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3392-6881","authenticated-orcid":false,"given":"Alexandre Rezende","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Oral and Craniofacial Sciences University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511401622"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000007169"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317695533"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201061654\u20103"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201020556\u20102"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi132"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2485\/jhtb.14.227"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052252"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn121"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2018.12.004"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.5455\/jpma.5890"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-2931-9_3"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9121846"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476\u20104598\u20106\u201062"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aanat.2021.151724"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.4161\/org.4.2.5851"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20489"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601\u20100825.2011.01789.x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0042\u201096862004000300011"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510363373"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13153696"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2009.0022"},{"key":"e_1_2_9_24_1","doi-asserted-by":"crossref","unstructured":"Menon R. 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