{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:04:08Z","timestamp":1792206248555,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R34AI155318"],"award-info":[{"award-number":["R34AI155318"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Until now, the clinically relevant improvement for the Xerostomia Inventory (XI) has not been defined. Therefore, our aim was to determine the Minimally Important Difference (MID) of the XI for improvement in dry\u2010mouth symptoms in SjD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>The study recruited 34 SjD patients who underwent sialendoscopy of major salivary glands and 15 SjD patients in a nonintervention control group. XI scores were assessed at several time points. The MID was determined from the mean difference in XI scores between the groups with and without improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the control group, no significant XI score changes were seen. In the sialendoscopy group, a clinically relevant XI score change of four scale points was identified after 1\u2009week. For a prolonged duration (\u226516\u2009weeks), a minimum reduction of seven scale points in the XI score was required to indicate clinically relevant improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In SjD patients, a minimum change of four points in the XI score indicates a clinically relevant improvement for evaluating short\u2010term effects. For prolonged effects, a clinically relevant improvement requires a MID of seven points. The determination of the MID in XI could assist in future studies that evaluate changes in xerostomia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14841","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T23:15:19Z","timestamp":1703632519000},"page":"4356-4363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The minimally important difference for the Xerostomia Inventory among Sj\u00f6gren's disease patients"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1531-8930","authenticated-orcid":false,"given":"Zainab","family":"Assy","sequence":"first","affiliation":[{"name":"Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam University of Amsterdam and VU University Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0588-6843","authenticated-orcid":false,"given":"William Murray","family":"Thomson","sequence":"additional","affiliation":[{"name":"Sir John Walsh Research Institute University of Otago Faculty of Dentistry  Dunedin New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk S.","family":"Brand","sequence":"additional","affiliation":[{"name":"Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam University of Amsterdam and VU University Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghee","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diagnostic Sciences, Center for Orphaned Autoimmune Disorders University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2288-6984","authenticated-orcid":false,"given":"Merve M.","family":"Susam","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology and Pharmacy, Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3246-6353","authenticated-orcid":false,"given":"Gary A.","family":"Weisman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Christopher S. Bond Life Sciences Center University of Missouri  Columbia Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2581-4361","authenticated-orcid":false,"given":"Arjan","family":"Vissink","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, University Medical Center Groningen University of Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9453-4630","authenticated-orcid":false,"given":"Floris J.","family":"Bikker","sequence":"additional","affiliation":[{"name":"Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam University of Amsterdam and VU University Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3006-2128","authenticated-orcid":false,"given":"Derk Hendrik Jan","family":"Jager","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery\/Oral Pathology, Amsterdam UMC Location Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Amsterdam Institute for Infection and Immunity Inflammatory Diseases  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,26]]},"reference":[{"issue":"12","key":"e_1_2_12_2_1","first-page":"2225","article-title":"Selection of study endpoints and patients for clinical trials in primary Sj\u00f6gren's syndrome","volume":"40","author":"Arends S.","year":"2022","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40095"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12911"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515609070"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.23917"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.29233"},{"issue":"8","key":"e_1_2_12_8_1","article-title":"Interventions for the management of dry mouth: Non\u2010pharmacological interventions","volume":"30","author":"Furness S.","year":"2013","journal-title":"The Cochrane Database of Systematic Reviews"},{"issue":"12","key":"e_1_2_12_9_1","article-title":"Interventions for the management of dry mouth: Topical therapies","volume":"7","author":"Furness S.","year":"2011","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.14639\/0392-100X-1605"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30550"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2015.12.019"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-017-4854-7"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212672"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa284"},{"issue":"2","key":"e_1_2_12_16_1","first-page":"75","article-title":"Understanding of xerostomia and strategies for the development of artificial saliva","volume":"17","author":"Kho H. 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