{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:53Z","timestamp":1772160833888,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The symptoms of herpes simplex viruses type 1 (HSV\u20101) infections might be severe and persistent in immunocompromised patients in whom they reactivate at a high frequency. The development of Acyclovir (ACV) resistant strains due to long\u2010term treatment with antiviral agents in those patients is not uncommon. The aim of the present study was to assess the virucidal effect of commercially available mouthwashes against ACV\u2010resistant HSV\u20101 strains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Two acyclovir\u2010resistant HSV\u20101 strains were exposed for 30\u2009s to essential oil\u2010based (Listerine Fresh Burst\u00ae and Listerine Zero\u00ae), chlorhexidine gluconate 0.2% (Hexidyl\u00ae) and povidone\u2010iodine 7.5% (Betadine Gargle\u00ae) mouthwashes. Loss of virus infectivity was determined by means of plaque reduction assays in a cell culture system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All 4 of the tested solutions significantly reduced virus infectivity, with the essential oil\u2010based and povidone\u2010iodine mouthwashes being slightly more efficacious, compared to chlorhexidine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings of this analysis revealed that the tested oral rinses demonstrated in\u2010vitro antiviral activity against ACV\u2010resistant HSV. Comparative clinical trials are required to establish the clinical effectiveness of daily use of oral rinses in reducing the appearance of oral HSV lesions in immunocompromised patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14843","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T18:59:50Z","timestamp":1703703590000},"page":"4762-4766","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Virucidal effect of mouthwash on acyclovir\u2010resistant herpes simplex virus"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9924-5558","authenticated-orcid":false,"given":"M.","family":"Bar\u00a0Ilan","sequence":"first","affiliation":[{"name":"Oral Medicine Unit Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"Oral Medicine Unit, Department of Maxillofacial Surgery Tel Aviv Sourasky Medical Center  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Dovrat","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory Ministry of Health, Sheba Medical Center  Tel\u2010Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Central Virology Laboratory Ministry of Health, Sheba Medical Center  Tel\u2010Hashomer Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Georgaki","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine &amp; Pathology and Hospital Dentistry, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2227-0127","authenticated-orcid":false,"given":"E.","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine &amp; Pathology and Hospital Dentistry, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. G.","family":"Nikitakis","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine &amp; Pathology and Hospital Dentistry, School of Dentistry National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9771-7857","authenticated-orcid":false,"given":"N.","family":"Yarom","sequence":"additional","affiliation":[{"name":"Oral Medicine Unit Sheba Medical Center  Tel\u2010Hashomer Israel"},{"name":"School of Dental Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104421"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690030901"},{"issue":"4","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","DOI":"10.1002\/mbo3.459","article-title":"Antibacterial, antifungal, and antiviral effects of three essential oil blends","volume":"6","author":"Brochot A.","year":"2017","journal-title":"Microbiology"},{"key":"e_1_2_8_5_1","first-page":"80","article-title":"The solution is a solution","volume":"24","author":"Dovrat S.","year":"2022","journal-title":"The Israel Medical Association Journal"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-014-2378-x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3264-5"},{"key":"e_1_2_8_8_1","first-page":"27","volume-title":"Human herpesviruses: Biology, therapy, and immunoprophylaxis","author":"Fenyong L.","year":"2007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2014.08.013"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12707"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(02)00263-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1787"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2016.05.006"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000501062"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2010.07.001"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.386"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-023-04953-z"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.14843","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T02:12:25Z","timestamp":1736993545000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.14843"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,27]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/odi.14843"],"URL":"https:\/\/doi.org\/10.1111\/odi.14843","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ODI.14843\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14843\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14843\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14843\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14843\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14843\/v2\/response1","asserted-by":"object"}]},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,27]]},"assertion":[{"value":"2023-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}