{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:07Z","timestamp":1772160847368,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103405"],"award-info":[{"award-number":["82103405"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82141108"],"award-info":[{"award-number":["82141108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare the clinicopathological, molecular, and immune features of conventional and high\u2010grade transformation (HGT) secretory carcinoma (SC) in salivary glands.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      The clinicopathological data of 88 cases including 74 conventional SCs and 14 SCs with HGT were reviewed. Targeted next\u2010generation sequencing was performed in 11 SCs with HGT and 7 conventional SCs. The level of PD\u2010L1 and CD8\n                      <jats:sup>+<\/jats:sup>\n                      TILs was determined by immunohistochemistry.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with the conventional group, the rates of nodal metastasis, local recurrence, distant metastasis and mortality were significantly higher in the HGT cohort. Mutations of\n                      <jats:italic>ARID1A\/B, KMT2A, HOXD13, NRG1<\/jats:italic>\n                      and\n                      <jats:italic>ETV6<\/jats:italic>\n                      genes were identified in HGT SCs. A recurrent\n                      <jats:italic>E307G<\/jats:italic>\n                      mutation in\n                      <jats:italic>GATA6<\/jats:italic>\n                      gene was also observed in two cases. Two deceased HGT patients with distant metastasis harboured\n                      <jats:italic>NOTCH3<\/jats:italic>\n                      mutations.\n                      <jats:italic>ETV6\u2010RET<\/jats:italic>\n                      translocation was prone to occur in the HGT SCs. Additionally, PD\u2010L1 expression was low, and CD8\n                      <jats:sup>+<\/jats:sup>\n                      TILs were sparse in most HGT cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings reveal novel gene alterations involved in the progression of HGT in SCs. Most HGT SCs patients cannot benefit from PD\u2010L1 blocking and may be approached with a distinct treatment strategy including the lymph node dissection and application of molecular target drugs in precision oncology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14876","type":"journal-article","created":{"date-parts":[[2024,1,24]],"date-time":"2024-01-24T00:08:35Z","timestamp":1706054915000},"page":"4320-4330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The genetic and immune features of salivary gland secretory carcinoma with high\u2010grade transformation"],"prefix":"10.1111","volume":"30","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Stomatology, Department of Oral Pathology, Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 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