{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:02Z","timestamp":1772160842023,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the immunohistochemical expression of YAP and its correlation with markers involved in cell proliferation and apoptosis in benign epithelial odontogenic lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>\n                      The sample consisted of 95 cases of odontogenic lesions (25 dentigerous cysts, 30 non\u2010syndromic odontogenic keratocysts, 30 conventional ameloblastomas, and 10 unicystic ameloblastomas) and 10 dental follicles used as normal odontogenic tissue. The histological sections were submitted to immunohistochemistry with YAP, cyclin D1, Ki\u201067, and Bcl\u20102 antibodies. Immunoexpression was analyzed qualitatively and quantitatively using an adapted method. The collected data were analyzed descriptively and statistically (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The highest YAP expression was observed in odontogenic keratocysts, followed by unicystic ameloblastomas and conventional ameloblastomas, which exhibited moderate immunoreactivity predominantly in peripheral cells. Furthermore, significant differences in YAP immunoexpression were observed between the groups analyzed, with significant positive correlations between YAP and cyclin D1 in dentigerous cysts and unicystic ameloblastomas and between YAP and Ki\u201067 in unicystic ameloblastomas (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). However, there were no statistically significant correlations between YAP and Bcl\u20102 immunoexpression in the groups studied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>YAP may influence epithelial cell proliferation in odontogenic cysts and tumors, suggesting its possible participation in the progression of the odontogenic lesions studied.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14882","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:59:49Z","timestamp":1706749189000},"page":"4538-4546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Does\n                    <scp>YAP<\/scp>\n                    influence cell proliferation and apoptosis in benign epithelial odontogenic lesions?"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6762-135X","authenticated-orcid":false,"given":"Rani Iani Costa","family":"Gon\u00e7alo","sequence":"first","affiliation":[{"name":"Department of Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7600-4321","authenticated-orcid":false,"given":"Julliany Taverny","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Samily de Oliveira","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1392-4259","authenticated-orcid":false,"given":"Rodrigo Porpino","family":"Mafra","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janaina Lessa de Moraes dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-1434","authenticated-orcid":false,"given":"Leorik Pereira","family":"da Silva","sequence":"additional","affiliation":[{"name":"Oral Histopathology Service Federal University of Campina Grande  Patos PB Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e9lia Maria Guedes","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1201\/9780429258589"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010018\u20102693\u20106"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010018\u20102421\u20102"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23089"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13246249"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20201474"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.22138"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010020\u20100070\u2010z"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40169\u2010018\u20100202\u20109"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2019.12.017"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13237"},{"issue":"7","key":"e_1_2_10_13_1","first-page":"370","article-title":"Evaluation of Ki\u201067 and cyclin D1 expression in odontogenic keratocysts and orthokeratinised jaw cysts","volume":"67","author":"Gani F.","year":"2012","journal-title":"South African Dental Journal"},{"key":"e_1_2_10_14_1","volume-title":"Gnepp's diagnostic surgical pathology of the head and neck E\u2010book","author":"Gnepp D. 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