{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T23:54:47Z","timestamp":1787442887681,"version":"build-2736575974"},"reference-count":64,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009406","name":"Centre Hospitalier Universitaire de Nantes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009406","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022278","name":"Fondation des Gueules Cass\u00e9es","doi-asserted-by":"publisher","award":["2018\u201051"],"award-info":[{"award-number":["2018\u201051"]}],"id":[{"id":"10.13039\/501100022278","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Investigation of the therapeutic effect of zoledronic acid (ZA) in a preclinical model of jaw osteosarcoma (JO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The effect of 100\u2009\u03bcg\/kg ZA administered twice a week was assessed in a xenogenic mouse model of JO. The clinical (tumor growth, development of lung metastasis), radiological (bone microarchitecture by micro\u2010CT analysis), and molecular and immunohistochemical (TRAP, RANK\/RANKL, VEGF, and CD146) parameters were investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Animals receiving ZA exhibited an increased tumor volume compared with nontreated animals (71.3\u2009\u00b1\u200914.3\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      vs. 51.9\u2009\u00b1\u200919.9\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      at D14, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.06) as well as increased numbers of lung metastases (mean 4.88\u2009\u00b1\u20094.45 vs. 0.50\u2009\u00b1\u20091.07 metastases, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). ZA protected mandibular bone against tumor osteolysis (mean bone volume of 12.81\u2009\u00b1\u20090.53\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      in the ZA group vs. 11.55\u2009\u00b1\u20091.18\u2009mm\n                      <jats:sup>3<\/jats:sup>\n                      in the control group;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01). ZA induced a nonsignificant decrease in mRNA expression of the osteoclastic marker TRAP and an increase in RANK\/RANKL bone remodeling markers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of bisphosphonates in the therapeutic strategy for JO should be further explored, as should the role of bone resorption in the pathophysiology of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14897","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T08:34:00Z","timestamp":1708418040000},"page":"4209-4219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Zoledronic acid enhances tumor growth and metastatic spread in a mouse model of jaw 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