{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T09:43:18Z","timestamp":1777974198555,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess long\u2010term efficacy and side effects of pilocarpine on irradiated head and neck cancer (HNC) patients in both for prevention and treatment of radiation\u2010induced xerostomia (RIX).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective observational study was conducted. Eligibility criteria included irradiated HNC patients who received pilocarpine at least 12\u2009weeks either for prevention (group A) or for treatment (group B) of RIX. We collected the documented Late Effect Normal Tissue Task Force\u2010Subjective, Objective, Management, Analytics subjective\/objective grades of RIX before (only group B) and the latest visit for pilocarpine prescription, dosage, side effects, duration of treatment, and the cause of discontinuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between December 2007 and June 2022, 182 patients were enrolled including 95 patients (52%) in group A and 87 patients (48%) in group B. Group A patients reported grades 1, 2, 3, and 4 objective RIX in 0%, 7%, 93%, and 0%. Grade 1, 2, and 3 subjective RIX were 57%, 28%, and 15%. All patients in group B had grade 3 both objective\/subjective RIX. The overall improvement of objective\/subjective RIX was found in 40%\/83%. Discontinuation was found in 51% of patients due to tolerable symptoms or deterioration of the patient's status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on this retrospective analysis, long\u2010term use of pilocarpine in irradiated HNC appears feasible for both prevention and treatment of RIX.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14905","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:13:23Z","timestamp":1708992803000},"page":"4312-4319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A real\u2010life experience of long\u2010term use of pilocarpine in irradiated head and neck cancer patients"],"prefix":"10.1111","volume":"30","author":[{"given":"Rungarun","family":"Kittichet","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Prince of Songkhla University  Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8552-0149","authenticated-orcid":false,"given":"Imjai","family":"Chitapanarux","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"},{"name":"Northern Thai Research Group of Radiation Oncology (NTRG\u2010RO), Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kittikun","family":"Kittidachanan","sequence":"additional","affiliation":[{"name":"Northern Thai Research Group of Radiation Oncology (NTRG\u2010RO), Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patumrat","family":"Sripan","sequence":"additional","affiliation":[{"name":"Research Institute for Health Sciences Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.12.076"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.06.016"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2015.09.014"},{"key":"e_1_2_12_5_1","first-page":"1410","article-title":"Effect of oral pilocarpine on post\u2010irradiation xerostomia in head and neck cancer patients: A single\u2010center, single\u2010blind clinical trial","volume":"91","author":"Chitapanarux I.","year":"2008","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00104-4"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-6-125"},{"key":"e_1_2_12_8_1","first-page":"3","article-title":"A multicenter maintenance study of oral pilocarpine tablets for radiation\u2010induced xerostomia","volume":"10","author":"Jacobs C. 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