{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:29:08Z","timestamp":1790011748086,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,24]],"date-time":"2024-03-24T00:00:00Z","timestamp":1711238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis aimed to evaluate the clinical and mycological effectiveness of mucoadhesives as vehicles for drugs or natural products in the treatment of oral candidiasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The search for articles was carried out in the Medline\/PubMed, SCOPUS, EMBASE, Web of Science, Cochrane Library, and SciELO databases before August 2023. We selected the studies, extracted the data, evaluated the study quality, graded the evidence, performed the risk of bias, and carried out meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 389 potentially relevant articles were identified, and 11 studies (1869 participants) met the inclusion criteria of the systematic review. The overall risk of bias was considered low. The most common presentation of mucoadhesives was tablets, with miconazole being the most frequently drug used in the delivery system. Mucoadhesives demonstrated comparable efficacy with topical or systemic antifungal agents, with no significant differences between treatments in terms of clinical (RR\u2009=\u20090.907; 95CI\u2009=\u20090.3\u20131.297;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.591;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200964.648) or mycological (RR\u2009=\u20090.95; 95CI\u2009=\u20090.667\u20131.360;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.789;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200973.271) efficacy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mucoadhesives may be a suitable alternative to conventional treatments, with the advantage of reducing the frequency of application by up to 5 times and the daily dosage by up to 20 times.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14928","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T02:00:40Z","timestamp":1711332040000},"page":"3771-3787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mucoadhesive delivery systems for oral candidiasis treatment: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"30","author":[{"given":"Carolina Yoshi Campos","family":"Sugio","sequence":"first","affiliation":[{"name":"Department of Prosthodontics and Periodontics, Bauru School of Dentistry University of S\u00e3o Paulo (USP)  Bauru Brazil"},{"name":"BoneLab\u2010Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, Associated Laboratory for Green Chemistry\/Network of Chemistry and Technology (LAQV\/REQUIMTE) University of Porto (UP)  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Aparecida Maia Neves","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics, Bauru School of Dentistry University of S\u00e3o Paulo (USP)  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaryssa Akemi de Araujo","family":"Kitamoto","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics, Bauru School of Dentistry University of S\u00e3o Paulo (USP)  Bauru Brazil"},{"name":"BoneLab\u2010Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, Associated Laboratory for Green Chemistry\/Network of Chemistry and Technology (LAQV\/REQUIMTE) University of Porto (UP)  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel Ferreira","family":"Santiago\u00a0J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Health Sciences Centro Universit\u00e1rio Sagrado Cora\u00e7\u00e3o (UNISAGRADO)  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics, Bauru School of Dentistry University of S\u00e3o Paulo (USP)  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius Carvalho","family":"Porto","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics, Bauru School of Dentistry University of S\u00e3o Paulo (USP)  Bauru Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Migliorini","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Dentistry State University of Ponta Grossa (UEPG)  Ponta Grossa 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