{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:37:45Z","timestamp":1791279465028,"version":"4.1.0"},"reference-count":66,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Peri\u2010implantitis is one of the most common complications of implants. However, its pathogenesis has not been clarified. In recent years, mouse models are gradually being used in the study of peri\u2010implantitis. This review aims to summarize the methods used to induce peri\u2010implantitis in mice and their current applications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Articles of peri\u2010implantitis mouse models were collected. We analyzed the various methods of inducing peri\u2010implantitis and their application in different areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most researchers have induced peri\u2010implantitis by silk ligatures. Some others have induced peri\u2010implantitis by\n                      <jats:italic>Pg<\/jats:italic>\n                      gavage and LPS injection. Current applications of peri\u2010implantitis mouse models are in the following areas: investigation of pathogenesis and exploration of new interventions, comparison of peri\u2010implantitis with periodontitis, the interaction between systemic diseases and peri\u2010implantitis, etc.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Silk ligature for 2\u20134\u2009weeks,\n                      <jats:italic>Pg<\/jats:italic>\n                      gavage for 6\u2009weeks, and LPS injection for 6\u2009weeks all successfully induced peri\u2010implantitis in mice. Mice have the advantages of mature gene editing technology, low cost, and short time to induce peri\u2010implantitis. It has applications in the study of pathogenesis, non\u2010surgical treatments, and interactions with other diseases. However, compared with large animals, mice also have a number of disadvantages that limit their application.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14929","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T06:03:05Z","timestamp":1710828185000},"page":"3788-3798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Development and applications of peri\u2010implantitis mouse models"],"prefix":"10.1111","volume":"30","author":[{"given":"Jianwei","family":"Zhang","sequence":"first","affiliation":[{"name":"Stomatology Hospital, School of Stomatology Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou 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Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianming","family":"Chen","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5352-2046","authenticated-orcid":false,"given":"Misi","family":"Si","sequence":"additional","affiliation":[{"name":"Stomatology Hospital, School of Stomatology Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering 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