{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:28:19Z","timestamp":1780320499344,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,11]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Chronic graft\u2010versus\u2010host disease (cGVHD) is a leading cause of morbidity and mortality following allogeneic hematopoietic cell transplantation (alloHCT). The sclerodermatous form of cGVHD can be particularly debilitating; however, orofacial sclerodermatous involvement remains poorly described.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To characterize orofacial features of sclerodermatous cGVHD in a single center cohort of patients who underwent alloHCT.<\/jats:p>\n <\/jats:sec>\n \n Study Design<\/jats:title>\n Retrospective data were collected from electronic medical records and analyzed descriptively.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n There were 39 patients who received alloHCT between 1993 and 2017 and developed orofacial sclerodermatous cGVHD. Concomitant cutaneous sclerodermatous cGVHD was common (\n n<\/jats:italic>\n \u2009=\u200920, 51%). Orofacial sclerodermatous cGVHD features included fibrous bands of the buccal mucosa (\n n<\/jats:italic>\n \u2009=\u200923, 59%), limited mouth opening (\n n<\/jats:italic>\n \u2009=\u200919, 54%), perioral fibrosis (\n n<\/jats:italic>\n \u2009=\u20098, 21%), and focal gingival recession (\n n<\/jats:italic>\n \u2009=\u20094, 10%). Oral mucosal fibrosis was observed at the site of active or resolved chronic lichenoid inflammation in 30 patients, with all but two also presenting with a history of ulcerations. Management included jaw stretching exercises (\n n<\/jats:italic>\n \u2009=\u200910; 6 stable\/improved), surgery (\n n<\/jats:italic>\n \u2009=\u20093; 2 improved), and intralesional corticosteroid injections (\n n<\/jats:italic>\n \u2009=\u20092; 2 improved).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Orofacial involvement with sclerodermatous cGVHD can present with multiple manifestations including fibrous banding, limited mouth opening, perioral fibrosis, and focal gingival recession. Surgical and non\u2010surgical management strategies may improve clinical function and reduce morbidity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/odi.14932","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T01:05:09Z","timestamp":1711069509000},"page":"5082-5090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characterization of orofacial features in sclerodermatous chronic\n graft\u2010versus\u2010host<\/scp>\n disease"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5617-1090","authenticated-orcid":false,"given":"Amal","family":"Bajonaid","sequence":"first","affiliation":[{"name":"College of Dentistry Jazan University Jazan Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Guntaka","sequence":"additional","affiliation":[{"name":"OMFS Candidate Mount Sinai Health System New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Harper","sequence":"additional","affiliation":[{"name":"Department of Developmental Biology Harvard School of Dental Medicine Boston Massachusetts USA"},{"name":"Department of Dentistry Boston Children's Hospital Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Cutler","sequence":"additional","affiliation":[{"name":"Division of Stem Cell Transplantation and Cellular Therapy Dana\u2010Farber Cancer Institute Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Duncan","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber\/Boston Children's Cancer and Blood Disorders Center Boston Massachusetts 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