{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:35:28Z","timestamp":1791941728306,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013928","name":"Instituto Milenio en Inmunolog\u00eda e Inmunoterapia","doi-asserted-by":"publisher","award":["ICN 09_016\/ICN 2021_045"],"award-info":[{"award-number":["ICN 09_016\/ICN 2021_045"]}],"id":[{"id":"10.13039\/501100013928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023251","name":"VID vitenskapelige h\u00f8gskole","doi-asserted-by":"publisher","award":["ENL05\/22"],"award-info":[{"award-number":["ENL05\/22"]}],"id":[{"id":"10.13039\/501100023251","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","award":["ICN2021_045"],"award-info":[{"award-number":["ICN2021_045"]}],"id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022105","name":"Oral Reconstruction Foundation","doi-asserted-by":"publisher","award":["42004"],"award-info":[{"award-number":["42004"]}],"id":[{"id":"10.13039\/501100022105","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the distribution of macrophages, neutrophils, NK cells, and blood vessels in peri\u2010implantitis compared to healthy aged gingiva samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This observational study included eight gingival samples from peri\u2010implantitis and eight from periodontally healthy individuals. By immunofluorescence were identified neutrophils, NK cells, macrophages, and their pro\u2010inflammatory or pro\u2010healing phenotypes, and blood vessels. Two ROIs were designated as zone 1, connective tissue closest to the epithelium and zone 2, connective tissue over 200 microns from the rete ridges. Immune cells and vascular structures were quantified and characterized according to their distribution in both zones.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two peri\u2010implantitis zones were characterized by unique macrophage phenotypes and blood vessel architecture. Blood vessels were larger in zone 2 in peri\u2010implantitis. A greater number of NK cells and macrophages were found in peri\u2010implantitis compared to healthy aged samples. A higher presence of pro\u2010inflammatory macrophages was found in zone 1 compared to zone 2. A similar proportion of pro\u2010inflammatory and pro\u2010healing macrophages were found in zone 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A specific distribution for pro\u2010inflammatory macrophages and vascular architecture is observed in peri\u2010implantitis. TNF\u2010\u03b1 colocalizes with macrophages in the connective tissue near rete ridges. NK cells are more abundant in peri\u2010implantitis than in healthy samples.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14935","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T23:44:48Z","timestamp":1712101488000},"page":"5305-5314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Topological insight of immune\u2010vascular distribution in peri\u2010implantitis lesions"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0020-0710","authenticated-orcid":false,"given":"Veronica","family":"Villalobos","sequence":"first","affiliation":[{"name":"Program of Molecular and Cell Biology, Faculty of Medicine, Institute of Biomedical Sciences (ICBM) Universidad de Chile  Santiago Chile"},{"name":"Millennium Institute on Immunology and Immunotherapy (IMII) Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Silva","sequence":"additional","affiliation":[{"name":"Program of Molecular and Cell Biology, Faculty of Medicine, Institute of Biomedical Sciences (ICBM) Universidad de Chile  Santiago Chile"},{"name":"Millennium Institute on Immunology and Immunotherapy (IMII) Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Morales","sequence":"additional","affiliation":[{"name":"Program of Molecular and Cell Biology, Faculty of Medicine, Institute of Biomedical Sciences (ICBM) Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javiera","family":"Canelo","sequence":"additional","affiliation":[{"name":"Program of Molecular and Cell Biology, Faculty of Medicine, Institute of Biomedical Sciences (ICBM) Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9971-7084","authenticated-orcid":false,"given":"Mauricio","family":"Garrido","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy (IMII) Universidad de Chile  Santiago Chile"},{"name":"Faculty of Dentistry, Department of Conservative Dentistry Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2037-7158","authenticated-orcid":false,"given":"Leandro J.","family":"Carre\u00f1o","sequence":"additional","affiliation":[{"name":"Millennium Institute on Immunology and Immunotherapy (IMII) Universidad de Chile  Santiago Chile"},{"name":"Program of Immunology, Institute of Biomedical Sciences, Faculty of Medicine Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Cavalla","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Conservative Dentistry Universidad de Chile  Santiago Chile"},{"name":"Faculty of Dentistry Andres Bello University  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8343-0214","authenticated-orcid":false,"given":"Nicolas","family":"Dutzan","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Conservative Dentistry Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0456-0721","authenticated-orcid":false,"given":"Monica","family":"Caceres","sequence":"additional","affiliation":[{"name":"Program of Molecular and Cell Biology, Faculty of Medicine, Institute of Biomedical Sciences (ICBM) Universidad de Chile  Santiago Chile"},{"name":"Millennium Institute on Immunology and Immunotherapy (IMII) Universidad de Chile  Santiago Chile"},{"name":"Millennium Nucleus of Ion Channel\u2010Associated Diseases (MiNICAD)  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","first-page":"811","article-title":"Age influence on periodontal tissues: A histological study","volume":"54","author":"Andreescu C. 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