{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:01:46Z","timestamp":1791234106925,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate osteoradionecrosis (ORN) incidence in a cohort of patients undergoing tooth extraction (TE) before radiotherapy (RT) for head and neck cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study protocol was approved by the Ethics Committee of Universit\u00e0 Cattolica del Sacro Cuore (ID\u20102132) and registered at\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>\n                      (ID: NCT04009161). TE was performed in case of signs of pericoronitis, periapical lesions, restorative impossibility, severe periodontitis. ORN was defined as exposed bone at an unhealed post\u2010extraction socket in the absence of oncological recurrence. The RT plans were reviewed, and each post\u2010extractive socket was contoured to calculate the received radiation dose.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 156 patients with 610 TE were enrolled. The mean follow\u2010up was 567\u2009days. ORN was diagnosed in four patients (2.6% of patients and 0.7% of TE). Need for osteotomy and radiation dose at the extraction site were associated with ORN (OR for osteotomy: 21.9, 95% CI: 2.17\u2013222.2,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009; OR for RT dose: 1.1, 95% CI: 1\u20131.15,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TE appears to be a significant risk factor for ORN, particularly when osteotomy is required, and post\u2010extraction sockets receive a high RT dosage. This study proposes a decision\u2010making algorithm for TE and outlines a straightforward surgical protocol.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14941","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T08:07:20Z","timestamp":1712650040000},"page":"5129-5139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Osteoradionecrosis incidence in pre\u2010radiation teeth extractions: A prospective study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9928-4100","authenticated-orcid":false,"given":"C.","family":"Rupe","sequence":"first","affiliation":[{"name":"Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli\u2014IRCCS, School of Dentistry Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8637-2029","authenticated-orcid":false,"given":"G.","family":"Gioco","sequence":"additional","affiliation":[{"name":"Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli\u2014IRCCS, School of Dentistry Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Massaccesi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli\u2014IRCCS, Institute of Radiology Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tagliaferri","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli\u2014IRCCS, Institute of Radiology Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Pastore","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli\u2014IRCCS, Institute of Radiology Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Miccich\u00e9","sequence":"additional","affiliation":[{"name":"Oncologic Radiotherapy Ospedale Isola Tiberina Gemelli Isola  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Galli","sequence":"additional","affiliation":[{"name":"Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli\u2014IRCCS, Institute of Otolaryngology Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Mele","sequence":"additional","affiliation":[{"name":"Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli\u2014IRCCS, Institute of Otolaryngology Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Specchia","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli\u2014IRCCS Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cassano","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Fondazione Policlinico Universitario A. 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