{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:41:45Z","timestamp":1788633705334,"version":"build-2803163510"},"reference-count":63,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971275"],"award-info":[{"award-number":["81971275"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Emerging evidence supports the association between periodontitis and depression, although the mechanisms are unclear. This study investigated the role of SorCS2 in the pathogenesis of periodontitis\u2010induced depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>An experimental periodontitis model was established using SorCS2 knockout mice and their wild\u2010type littermates, and depression\u2010like behaviour was evaluated. The expression of proBDNF signalling, neuronal activity, and glutamate\u2010associated signalling pathways were further measured by western blotting and immunofluorescence. In addition, neuroinflammatory status, astrocytic and microglial markers, and the expression of corticosterone\u2010related factors were measured by immunofluorescence, western blotting, and enzyme\u2010linked immunosorbent assays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>SorCS2 deficiency alleviated periodontitis\u2010induced depression\u2010like behaviour in mice. Further results suggested that SorCS2 deficiency downregulated the expression of pro\u2010BDNF and glutamate signalling and restored neuronal activities in mice with periodontitis. Neuroinflammation in the mouse hippocampus was triggered by experimental periodontitis but was not affected by SorCS2 deficiency. The levels of corticosterone and the expression of glucocorticoid receptors were also not altered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study, for the first time, reveals the critical role of SorCS2 in the pathogenesis of periodontitis\u2010induced depression. The underlying mechanism involves proBDNF and glutamate signalling in the hippocampus, providing a novel therapeutic target for periodontitis\u2010associated depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14944","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T13:35:41Z","timestamp":1712151341000},"page":"5408-5420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>SorCS2<\/scp>\n                    is involved in promoting periodontitis\u2010induced depression\u2010like behaviour in mice"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1709-810X","authenticated-orcid":false,"given":"Yingxue","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology Xi'an Jiaotong University  Xi'an China"},{"name":"Department 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