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In\u00a0vivo experiments were conducted to analyze LRG1 localization in periodontitis patients. The correlation between the serum LRG1 levels and alveolar bone resorption in the mouse periodontitis model was also investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A positive correlation existed between the periodontal inflamed surface area and serum LRG1 levels (Spearman's rank correlation coefficient: 0.60). LRG1 mRNA expression in human gingival epithelial cells and fibroblasts was upregulated by\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      stimulation or tumor necrosis factor\u2010\u03b1 stimulation. Interleukin\u20106 in human gingival epithelial cells and fibroblasts induced the production of LRG1 and transforming growth factor\u2010\u03b2. LRG1 levels in the periodontal tissue and serum in the periodontitis model were higher than those in control mice. LRG1 local administration resulted in alveolar bone resorption, whereas the administration of interleukin\u20106R antibody inhibited bone resorption.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LRG1 levels in serum and periodontal tissue are upregulated in periodontitis and are implicated in periodontal tissue destruction through interleukin\u20106 production.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14952","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T11:08:37Z","timestamp":1713956917000},"page":"5294-5304","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Leucine\u2010rich alpha\u20102\u2010glycoprotein 1 affects bone destruction via\n                    <scp>IL<\/scp>\n                    \u20106 in mouse periodontitis model"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6796-884X","authenticated-orcid":false,"given":"Kazuhisa","family":"Ouhara","sequence":"first","affiliation":[{"name":"Department of Periodontal Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasuku","family":"Takemura","sequence":"additional","affiliation":[{"name":"Department of Periodontal Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Periodontal Medicine, Graduate School of Biomedical and Health Sciences Hiroshima University  Hiroshima 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