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In this regard, the aim of this study was to summarize the current evidence on the different forms of targeted therapy, effectiveness, and drawbacks of this course of treatment. Four databases were searched electronically without regard to publication date or language. Grey literature searches and manual searches were also undertaken. Publications with sufficient clinical data on targeted therapy for odontogenic tumors were required to meet the criteria for eligibility. The analysis of the data was descriptive. A total of 15 papers comprising 17 cases (15 ameloblastomas and 2 ameloblastic carcinomas) were included. Numerous mutations were found, with BRAF V600E being most common. Dabrafenib was the most utilized drug in targeted therapy. Except for one case, the treatment reduced the size of the lesion (16\/17 cases), showing promise. Most of the adverse events recorded were mild, such as skin issues, voice changes, abnormal hair texture, dry eyes, and systemic symptoms (e.g., fatigue, joint pain, and nausea). It is possible to reach the conclusion that targeted therapy for ameloblastoma and ameloblastic carcinoma may be a useful treatment strategy, based on the findings of the included studies.<\/jats:p>","DOI":"10.1111\/odi.14962","type":"journal-article","created":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:14:31Z","timestamp":1714608871000},"page":"3571-3581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Targeted therapies in ameloblastomas and ameloblastic carcinoma\u2014A systematic review"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9755-4779","authenticated-orcid":false,"given":"Ronell","family":"Bologna\u2010Molina","sequence":"first","affiliation":[{"name":"Diagnostic in Oral Pathology and Oral Medicine Department, School of Dentistry Universidad de la Republica (UDELAR)  Montevideo Uruguay"},{"name":"Members of an International Consortium on Odontogenic 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