{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:54:29Z","timestamp":1773867269666,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Carcinoma ex\u2010pleomorphic adenoma (CEXPA) represents a malignant transformation from a recurrent or primary pleomorphic adenoma (PA), and the immune response may be essential in this process. Therefore, in this study, we aimed to identify and quantify subpopulations of dendritic cells (DCs) in CEXPA, residual PA in CEXPA (rPA), and PA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A multicenter study was performed collecting salivary gland tumor (SGT) samples from three Oral and Maxillofacial Pathology Centers. A tissue microarray containing 41 samples of CEXPA and 22 samples of PA was included in this study and submitted to immunohistochemical reactions against CD1a, CD83, CD207, and Ki67 antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both PA and rPA showed a higher quantification of CD207+ and CD83+ cells when compared to CEXPA (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01, respectively). There was also a difference when comparing the cell proliferation index between PA\/rPA and CEXPA using the Ki\u201067 marker (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.043). However, there was no difference in the DC population regarding clinical parameters such as sex, anatomical location, size, and metastases (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.06).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Immunohistochemical profile of DC subpopulations and cell proliferation biomarkers in SGTs can contribute as an important tool in the differentiation of benign and malignant tumors or detection of initial areas with malignant transformation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14965","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T04:45:08Z","timestamp":1713933908000},"page":"5041-5049","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dendritic cell subpopulations in carcinoma ex\u2010pleomorphic adenoma: A multicenter study"],"prefix":"10.1111","volume":"30","author":[{"given":"B\u00e1rbara Azevedo","family":"Machado","sequence":"first","affiliation":[{"name":"Department of Dentistry Universidade Federal de Santa Catarina \u2013 UFSC  Florian\u00f3polis SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Guadalupe","family":"Gama\u2010Cuellar","sequence":"additional","affiliation":[{"name":"Department of Dentistry Universidade Federal de Santa Catarina \u2013 UFSC  Florian\u00f3polis SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9015-6831","authenticated-orcid":false,"given":"Jo\u00e3o Figueira","family":"Scarini","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Department Universidade de Campinas \u2013 UNICAMP  Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katya Pulido","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Dentistry Universidad Aut\u00f3noma de Baja California \u2013 UABC  Mexicali BC Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3694-5025","authenticated-orcid":false,"given":"Fernanda Viviane","family":"Mariano","sequence":"additional","affiliation":[{"name":"Anatomic Pathology Department Universidade de Campinas \u2013 UNICAMP  Campinas SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Luiz Cavalcanti","family":"Albuquerque\u2010Junior","sequence":"additional","affiliation":[{"name":"Department of Pathology Universidade Federal de Santa Catarina \u2013 UFSC  Florian\u00f3polis SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rog\u00e9rio","family":"Gondak","sequence":"additional","affiliation":[{"name":"Department of Pathology Universidade Federal de Santa Catarina \u2013 UFSC  Florian\u00f3polis SC Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1658\u20103876(09)50007\u20106"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.5005\/JP\u2010JOURNALS\u201010005\u20101776"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.CUB.2020.06.081"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-018-0925-3"},{"key":"e_1_2_10_6_1","volume-title":"Pleomorphic adenoma","author":"Bokhari M. 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