{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:23:15Z","timestamp":1789093395092,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270992"],"award-info":[{"award-number":["82270992"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071131"],"award-info":[{"award-number":["82071131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Salivary glands are frequently damaged in patients undergoing radiotherapy for head and neck cancer. Whether PANoptosis, which is characterized by pyroptosis, apoptosis, and necroptosis, occurs during radiation injury to the salivary glands and its role remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Radiation\u2010induced injury models of mouse submandibular gland, as well as primary acinar cells and HSG cell lines were established to determine the presence of radiation\u2010induced PANoptosis. Several programmed cell death inhibitors, PFT\u03b1, disulfiram, Nec\u20101 and zVAD, were used to compare the effects of different cell death pathway on radiation injury. The LEGENDplex\u2122 Human Inflammation Panel was used to characterize the inflammatory landscape secreted by salivary gland cells after radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Single 15Gy or 8Gy radiotherapy triggered PANoptosis in mouse submandibular gland or salivary gland cells. Compared to the suppression of pyroptosis, apoptosis, or necroptosis alone, the inhibition of PANoptosis is more effective in preventing radiation injury to the salivary glands (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). The levels of multiple inflammatory cytokines were significantly up\u2010regulated in the supernatants of HSG cells within 48\u2009h after IR. Neutralizing inflammatory cytokines are capable of inhibiting salivary glands PANoptosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Inhibition of PANoptosis induced by inflammatory cytokines can effectively prevent radiation injury of salivary glands.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14967","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T03:58:45Z","timestamp":1713931125000},"page":"5030-5040","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>PANoptosis<\/scp>\n                    induced by inflammatory cytokines promotes salivary glands radiation injury"],"prefix":"10.1111","volume":"30","author":[{"given":"Yi","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial &amp; Head and Neck Oncology Beijing Stomatological Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial &amp; Head and Neck Oncology Beijing Stomatological Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanzheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial &amp; Head and Neck Oncology Beijing Stomatological Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial &amp; Head and Neck Oncology Beijing Stomatological Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3561-7073","authenticated-orcid":false,"given":"Zhengxue","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial &amp; Head and Neck Oncology Beijing Stomatological Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8967-9862","authenticated-orcid":false,"given":"Lizheng","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial &amp; Head and Neck Oncology Beijing Stomatological Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9092050"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.11.067"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010022\u201005460\u2010x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.11.021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034521999298"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau1208"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.112899"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010019\u20101414\u20107"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.11.025"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.08.227"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10111666"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00406"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.91814"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2023.10.001"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u201003074\u20109"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345221112332"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010020\u201001628\u20104"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.05.005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.016"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13381"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.790"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11102050"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102687"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.14967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T09:46:00Z","timestamp":1733132760000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.14967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,24]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/odi.14967"],"URL":"https:\/\/doi.org\/10.1111\/odi.14967","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ODI.14967\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14967\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14967\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14967\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14967\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14967\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14967\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.14967\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,24]]},"assertion":[{"value":"2024-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}