{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T15:08:17Z","timestamp":1788966497436,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T00:00:00Z","timestamp":1715212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To perform a systematic review with meta\u2010analysis to assess recent scientific evidence on the association between periodontitis and systemic parameters\/conditions in individuals with chronic kidney disease (CKD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The search for studies was performed in MedLine\/PubMed, Scopus, Web of Science, and BIREME databases. Reference lists of selected articles were also searched. Studies with different epidemiological designs evaluating the influence of exposure to periodontitis on serum markers and mortality in individuals with CKD were eligible for inclusion. Three independent reviewers performed the article selection and data extraction. The assessment of methodological quality used the adapted Newcastle Ottawa Scale. Random effects meta\u2010analysis was performed to calculate association measurements and 95% confidence intervals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 3053 records were identified in the database search, with only 25 studies meeting the eligibility criteria and, of these, 10 studies contributed data for meta\u2010analysis. Using a random\u2010effects model, periodontitis was associated with hypoalbuminemia (PR\n                      <jats:sub>\n                        <jats:bold>unadjusted<\/jats:bold>\n                      <\/jats:sub>\n                      \u2009=\u20092.47; 95%CI:1.43\u20134.26), with high levels of C\u2010reactive protein (PR\n                      <jats:sub>\n                        <jats:bold>unadjusted<\/jats:bold>\n                      <\/jats:sub>\n                      \u2009=\u20091.35; 95%CI%:1.12\u20131.64), death from cardiovascular disease (RR\n                      <jats:sub>\n                        <jats:bold>unadjusted<\/jats:bold>\n                      <\/jats:sub>\n                      \u2009=\u20092.29; 95%CI:1.67\u20133.15) and death from all causes (RR\n                      <jats:sub>\n                        <jats:bold>unadjusted<\/jats:bold>\n                      <\/jats:sub>\n                      \u2009=\u20091.73; 95%CI:1.32\u20132.27).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The findings of this review validated a positive association between periodontitis and serum markers and mortality data in individuals with CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14981","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T03:09:27Z","timestamp":1715224167000},"page":"4078-4086","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Periodontitis and systemic parameters in chronic kidney disease: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4470-3168","authenticated-orcid":false,"given":"Su\u00e9lem Maria Santana Pinheiro","family":"Ferreira","sequence":"first","affiliation":[{"name":"Department of Health Feira de Santana State University (UEFS)  Feira de Santana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4270-8491","authenticated-orcid":false,"given":"Isaac Suzart","family":"Gomes\u2010Filho","sequence":"additional","affiliation":[{"name":"Department of Health Feira de Santana State University (UEFS)  Feira de Santana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7275-4280","authenticated-orcid":false,"given":"Maria da Concei\u00e7\u00e3o Nascimento","family":"Costa","sequence":"additional","affiliation":[{"name":"Institute of Collective Health Federal University of Bahia (UFBA)  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9410-5676","authenticated-orcid":false,"given":"Simone Seixas da","family":"Cruz","sequence":"additional","affiliation":[{"name":"Health Sciences Center Federal University of Rec\u00f4ncavo of Bahia  Santo Ant\u00f4nio de Jesus Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Lara","family":"Neves","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Federal University of Bahia (UFBA)  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3221-265X","authenticated-orcid":false,"given":"Carlos Alberto Lima da","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Health Feira de Santana State University (UEFS)  Feira de Santana Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4603-9109","authenticated-orcid":false,"given":"Kaio Vinicius Freitas de","family":"Andrade","sequence":"additional","affiliation":[{"name":"Department of Health Feira de Santana State University (UEFS)  Feira de Santana 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