{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T20:36:25Z","timestamp":1782506185653,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Object<\/jats:title>\n                    <jats:p>Mesenchymal stem cell (MSC) therapy is a potential strategy for promoting alveolar bone regeneration. This study evaluated the effects and mechanisms of transplanted MSCs on alveolar bone repair.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Mouse alveolar bone defect model was treated using mouse bone marrow mesenchymal stem cell (BMSC) transplantation. The bone repair was evaluated by micro\u2010CT and Masson staining. The conditioned medium of hypoxia\u2010treated BMSCs was co\u2010cultured with normal BMSCs in\u00a0vitro to detect the regulatory effect of transplanted MSCs on the chemotactic and migratory functions of host cells. The mechanisms were investigated using Becn siRNA transfection and western blotting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BMSC transplantation promoted bone defect regeneration. The hypoxic microenvironment induces BMSCs to release multiple extracellular vesicle (EV)\u2010mediated regulatory proteins that promote the migration of host stem cells. Protein array analysis, western blotting, GFP\u2010LC3 detection, and Becn siRNA transfection confirmed that autophagy activation in BMSCs plays a key role during this process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The local hypoxic microenvironment induces transplanted MSCs to secrete a large number of EV\u2010mediated regulatory proteins, thereby upregulating the migration function of the host stem cells and promoting alveolar bone defect regeneration. This process depends on the autophagy\u2010related mechanism of the transplanted MSCs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14982","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T06:24:26Z","timestamp":1715149466000},"page":"5221-5231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Transplanted\n                    <scp>MSCs<\/scp>\n                    promote alveolar bone repair via hypoxia\u2010induced extracellular vesicle secretion"],"prefix":"10.1111","volume":"30","author":[{"given":"Yitong","family":"Liu","sequence":"first","affiliation":[{"name":"Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology Capital Medical University  Beijing China"},{"name":"Immunology Research Center for Oral and Systemic Health, Beijing Friendship Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Periodontics Qinghai Provincial People's Hospital  Qinghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlin","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Periodontics Qinghai Provincial People's Hospital  Qinghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Periodontics Qinghai Provincial People's Hospital  Qinghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Periodontics Qinghai Provincial People's Hospital  Qinghai 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