{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:08Z","timestamp":1772160848770,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T00:00:00Z","timestamp":1715472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2022D007"],"award-info":[{"award-number":["2022D007"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetes is accompanied by a high prevalence of hyposalivation, causing severe damage to oral and systemic health. Mitochondrial dynamics play important roles in the pathogenesis of various diabetic complications; however, little is known about their roles in diabetic hyposalivation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A diabetic mouse model and a high glucose (HG)\u2010induced diabetic submandibular gland (SMG) cell model were employed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>More mitochondria surrounded by autophagosomes and higher expression of mitophagy\u2010related proteins were detected in the SMGs of diabetic mice and HG\u2010treated SMG cells. In diabetic SMGs, dynamin\u2010related protein 1 (DRP1) was upregulated, whereas mitofusin\u20102 was downregulated both in\u00a0vivo and in\u00a0vitro. Shortened mitochondria and impaired mitochondrial functions were observed in the HG group. A DRP1\u2010specific inhibitor, mdivi\u20101, suppressed mitochondrial fission and mitophagy, as well as restored mitochondrial functions in the HG condition. Moreover, the interaction of F\u2010actin and DRP1 was enhanced in the diabetic group. Inhibiting F\u2010actin with cytochalasin D repaired the injured effects of HG on mitochondrial dynamics and functions. Conversely, the F\u2010actin\u2010polymerization\u2010inducer jasplakinolide aggravated mitochondrial fission and dysfunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>F\u2010actin contributes to HG\u2010evoked mitochondrial fission by interacting with DRP1, which induces mitophagy and impairs mitochondrial function in SMG cells, ultimately damaging the SMG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.14983","type":"journal-article","created":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:59:05Z","timestamp":1715551145000},"page":"5429-5444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["F\u2010actin\/DRP1 axis\u2010mediated mitochondrial fission promotes mitophagy in diabetic submandibular glands"],"prefix":"10.1111","volume":"30","author":[{"given":"Hou\u2010Wei","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Xiamen Medical College Xiamen Key Laboratory of Stomotalogical Disease Diagnosis and Treatment  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Stomatological Hospital of Xiamen Medical College Xiamen Key Laboratory of Stomotalogical Disease Diagnosis and Treatment  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiu\u2010Fang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xiamen Key Laboratory of Stomotalogical Disease Diagnosis and Treatment Stomatological Hospital of Xiamen Medical College  Xiamen 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