{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:27:45Z","timestamp":1792686465649,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T00:00:00Z","timestamp":1716940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Exodontia is commonly considered as a risk factor for the development of medication\u2010related osteonecrosis of the jaw (MRONJ) in individuals exposed to bone modifying agents. This study was aimed at assessing the efficiency and safety of a gaseous oxygen\u2013ozone mixture as an adjuvant to a standard exodontia to reduce the risk of MRONJ development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized, open\u2010label, phase II, single\u2010center clinical trial involving 117 patients at risk of MRONJ was conducted. The study protocol tested injections of an oxygen\u2013ozone mixture in the post\u2010extraction site. Participants were randomly assigned to two groups: oxygen\u2010ozone therapy, and standard tooth extraction protocol. Post\u2010extraction wound healing was assessed using the Inflammatory Proliferative Remodeling (IPR) Wound Healing Scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The oxygen\u2010ozone therapy group exhibited a significant improvement in wound healing post\u2010extraction during the inflammatory and proliferative phases, as indicated by the IPR scale scores at 3\u20135\u2009days (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006) and 14\u2009days (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Oxygen\u2013ozone therapy shows promise in improving post\u2010extraction healing in patients at risk of MRONJ. Future studies with larger sample sizes and multicenter collaborations are recommended to confirm the validity of these findings and explore the long\u2010term efficacy of ozone therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15006","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T03:29:41Z","timestamp":1716953381000},"page":"5183-5194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Reduction of\n                    <scp>MRONJ<\/scp>\n                    risk after exodontia by virtue of ozone infiltration: A randomized clinical trial"],"prefix":"10.1111","volume":"30","author":[{"given":"Olga","family":"Di Fede","sequence":"first","affiliation":[{"name":"Department of Precision Medicine in Medical Surgical and Critical Care (Me.Pre.C.C.), University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3135-7462","authenticated-orcid":false,"given":"Gaetano","family":"La Mantia","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine in Medical Surgical and Critical Care (Me.Pre.C.C.), University of Palermo  Palermo Italy"},{"name":"Unit of Oral Medicine and Dentistry for Fragile Patients, Department of Rehabilitation, Fragility and Continuity of Care University Hospital Palermo  Palermo Italy"},{"name":"Department of Biomedical and Dental Sciences and Morphofunctional Imaging University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmine","family":"Del Gaizo","sequence":"additional","affiliation":[{"name":"Private Practice  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4008-6502","authenticated-orcid":false,"given":"Rodolfo","family":"Mauceri","sequence":"additional","affiliation":[{"name":"Department of Precision Medicine in Medical Surgical and Critical Care (Me.Pre.C.C.), University of Palermo  Palermo Italy"},{"name":"Unit of Oral Medicine and Dentistry for Fragile Patients, Department of Rehabilitation, Fragility and Continuity of Care University Hospital Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenica","family":"Matranga","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Sciences and Mother\u2010Child Care \u201cG. 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