{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:07:34Z","timestamp":1790014054936,"version":"4.0.1"},"reference-count":59,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T00:00:00Z","timestamp":1717891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated the effect of metabolic syndrome (MetS) on periodontal clinical parameters and salivary biomarkers' matrix metalloproteinase\u20108 (MMP\u20108) and myeloperoxidase (MPO) in patients with periodontitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 120 participants aged 25\u201355 were categorized into three groups: MetS with periodontitis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940); systemically healthy with periodontitis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940); and systemically and periodontally healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200940). Data collected included systemic parameters like waist circumference (WC), blood pressure (BP), high\u2010 and low\u2010density lipoproteins, triglycerides (TG), fasting blood sugar (FBS), and glycated hemoglobin (HbA1c). Periodontal parameters estimated included bleeding on probing score (BoP), full\u2010mouth plaque score (FMPS), periodontal probing depth (PPD), clinical attachment loss (CAL), and the number of missing teeth. Unstimulated whole saliva was analyzed via ELISA for active MMP\u20108 (aMMP\u20108), total MMP\u20108 (tMMP\u20108), and MPO.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants with MetS and periodontitis exhibited significantly higher periodontal parameters, salivary aMMP\u20108, and MPO (26.26 vs. 24.1\u2009ng\/mL and 13.53 vs. 11.55\u2009ng\/mL compared to systemically healthy periodontitis patients) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Positive correlations occurred between aMMP\u20108 and WC, TG, and FBS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), and between MPO and WC, BP, and TG (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The positive associations between these biomarkers and metabolic parameters indicate their potential utility for monitoring cardiovascular and glycemic risk in patients with periodontal disease.<\/jats:p>\n                  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