{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T21:26:22Z","timestamp":1777325182737,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T00:00:00Z","timestamp":1717891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>In order to enhance clinical improvement of periodontal defects, the addition of enamel matrix derivatives (EMD) to open flap debridement (OFD) has been investigated. The aim of this systematic review is to figure out whether such a combination, in comparison to the treatment with OFD alone has some effects on the following outcomes: clinical attachment level gain, probing depth reduction, and gingival recessions increase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electronic databases (PubMed, Embase, Web of Science, and Cochrane) were searched for randomized controlled trials in humans addressing the use of a combination of OFD and EMD versus a control group with OFD alone for the treatment of periodontal defects, with a minimum of 6\u2009months of follow\u2010up; meta\u2010analysis and trial sequential analysis were then performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>From a total of 204 records screened by title and abstract, 13 studies were read full\u2010text and eight out of them included in the meta\u2010analysis. Some significant differences have been demonstrated both for clinical attachment level gain and probing depth reduction between test and control groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In the treatment of periodontal defects, the addition of EMD to OFD seems to be beneficial in terms of clinical attachment level gain, probing depth reduction, promoting periodontal regeneration. However, such results should be considered with caution because of the small number of studies included in the meta\u2010analysis and their heterogeneity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15029","type":"journal-article","created":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T12:43:46Z","timestamp":1717937026000},"page":"4113-4125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of OFD with EMD for treatment of periodontal defects: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2561-2325","authenticated-orcid":false,"given":"Ziyue","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tea Plant Biology and Utilization School of Tea and Food Science and Technology, Anhui Agricultural University  Hefei Anhui China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lifang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Stomatology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,9]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2012.728245"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1986.tb01461.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2008.01202.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2010.01614.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202111_27102"},{"issue":"2","key":"e_1_2_12_7_1","first-page":"125","article-title":"Treatment of infrabony defects with or without enamel matrix proteins: A 24\u2010month follow\u2010up randomized pilot study","volume":"41","author":"Chambrone D.","year":"2010","journal-title":"Quintessence International"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1806\u201083242007000300009"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.120753"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202308848"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003875"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2009.01451.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.1.25"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514564186"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"issue":"1","key":"e_1_2_12_17_1","first-page":"29","article-title":"A revised tool for assessing risk of bias in randomized trials. 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