{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:32Z","timestamp":1787015972135,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T00:00:00Z","timestamp":1717891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018713","name":"Center for Innovative Medicine","doi-asserted-by":"publisher","award":["FoUI\u2010954540"],"award-info":[{"award-number":["FoUI\u2010954540"]}],"id":[{"id":"10.13039\/501100018713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Calprotectin is elevated in saliva from inflammatory bowel disease (IBD) patients, but it is also affected by oral disease. We assessed the salivary concentration of calprotectin in IBD patients, in relation to intestinal and oral diseases. Furthermore, we investigated the phenotype of salivary neutrophils from IBD patients, and their ability to secrete calprotectin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Thirty IBD patients and 26 controls were orally examined and sampled for stimulated saliva. Twenty\u2010five IBD patients provided fresh fecal samples. Calprotectin concentrations in saliva and feces were determined by an enzyme\u2010linked immunosorbent assay. Expression of CD11b, CD15, and CD16 on oral neutrophils was assessed by flow cytometry. Secretion of calprotectin was evaluated in cultured oral neutrophils.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Calprotectin was significantly elevated in saliva of IBD patients compared to controls, particularly in Crohn's disease, irrespective of caries or periodontitis. Salivary calprotectin did not correlate to fecal calprotectin. CD11b expression was significantly reduced in salivary neutrophils from IBD patients. Salivary neutrophils from IBD patients tended to secrete more calprotectin than controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Salivary calprotectin is elevated in IBD regardless of oral diseases. Furthermore, salivary neutrophils secrete calprotectin, and display lower CD11b expression in IBD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15036","type":"journal-article","created":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T12:59:40Z","timestamp":1717937980000},"page":"286-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Salivary calprotectin and neutrophils in inflammatory bowel disease in relation to oral diseases"],"prefix":"10.1111","volume":"31","author":[{"given":"Mirjam","family":"Majster","sequence":"first","affiliation":[{"name":"Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Almer","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Division of Gastroenterology, Department of Gastroenterology, Dermatology and Rheumatology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Malmqvist","sequence":"additional","affiliation":[{"name":"Division of Oral Diseases, Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annsofi","family":"Johannsen","sequence":"additional","affiliation":[{"name":"Division of Oral Diseases, Department of Dental Medicine Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo","family":"Lira\u2010Junior","sequence":"additional","affiliation":[{"name":"Division of Oral Diagnostics and Rehabilitation, Department of Dental Medicine Karolinska Institutet  Stockholm 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