{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:45:55Z","timestamp":1791809155572,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270974"],"award-info":[{"award-number":["82270974"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The purpose of this study was to determine whether indoxyl sulfate (IS) is involved in alveolar bone deterioration and to elucidate the mechanism underlying alveolar bone loss in chronic kidney disease (CKD) patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Mice were divided into the control group, CP group (ligature\u2010induced periodontitis), CKD group (5\/6 nephrectomy), and CKD\u2009+\u2009CP group. The concentration of IS in the gingival crevicular fluid (GCF) was determined by HPLC. The bone microarchitecture was evaluated by micro\u2010CT. MC3T3\u2010E1 cells were stimulated with IS, and changes in mitochondrial morphology and ferroptosis\u2010related factors were detected. RT\u2010PCR, western blotting, alkaline phosphatase activity assays, and alizarin red S staining were utilized to assess how IS affects osteogenic differentiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with that in the other groups, alveolar bone destruction in the CKD\u2009+\u2009CP group was more severe. IS accumulated in the GCF of mice with CKD. IS activated the aryl hydrocarbon receptor (AhR) in\u00a0vitro, inhibited MC3T3\u2010E1 cell osteogenic differentiation, caused changes in mitochondrial morphology, and activated the SLC7A11\/GPX4 signaling pathway. An AhR inhibitor attenuated the aforementioned changes induced by IS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>IS activated the AhR\/SLC7A11\/GPX4 signaling pathway, inhibited osteogenesis in MC3T3\u2010E1 cells, and participated in alveolar bone resorption in CKD model mice through ferroptosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15050","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T07:36:49Z","timestamp":1719473809000},"page":"264-277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Indoxyl sulfate exacerbates alveolar bone loss in chronic kidney disease through ferroptosis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9802-2782","authenticated-orcid":false,"given":"Huiwen","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Periodontology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingli","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Research Institute of Stomatology  Shanghai China"},{"name":"Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai 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