{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:33:37Z","timestamp":1791855217559,"version":"4.3.4"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Oral leukoplakia (OL) is one of the most common and investigated oral potentially malignant disorders (OPMD). Preventing OSCC occurrence should be the primary outcome in the clinical management of OL. Surgical removal of OL is performed by most clinicians, although its effectiveness in reducing OSCC onset has still not been established by randomized controlled trials (RCT). Wait and see approach is characterized by frequent clinical examinations and periodical biopsies of OL, avoiding unnecessary surgical procedures.<\/jats:p>\n                    <jats:p>This is the first multicenter RCT in literature aiming at comparing the effectiveness of surgical removal and the \u201cwait and see\u201d approach in preventing OSCC onset in patients affected by dysplastic and non\u2010dysplastic OL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two Italian referral care centres for oral diseases were involved in this multicenter two\u2010arm RCT comparing the surgical removal of OL (group A) and the \u201cwait and see\u201d approach (group B), with the aim of reducing oral cancer onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This report shows preliminary data on the first 161 patients, with a mean follow\u2010up of 19.14\u2009\u00b1\u200911.25\u2009months. Eight cases of OSCC occurred (6 out 8 involving the tongue): one case in group A and seven cases in group B. Moreover, OL recurred in 13 (20%) cases after surgical excision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within the limitations of this preliminary report, these initial data underline the increased risk of OSCC onset in the case of OL of the tongue in the presence of epithelial dysplasia in group B (\u201cwait and see\u201d) compared to group A (surgery). This RCT is currently ongoing at the same clinical departments, with the aim of enrolling 310 patients and collecting data at 5\u2010year follow\u2010up, in order to achieve conclusive results, in an evidence\u2010based medicine approach.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15058","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T02:44:39Z","timestamp":1719542679000},"page":"807-814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Surgical treatment compared with \u201cwait and see\u201d in patients affected by oral leukoplakia to prevent oral cancer: Preliminary data from a multicenter randomized controlled trial"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8261-1179","authenticated-orcid":false,"given":"Niccol\u00f2","family":"Lombardi","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Biomediche Chirurgiche e Odontoiatriche Universit\u00e0 Degli Studi di Milano  Milan Italy"},{"name":"ASST Santi Paolo e Carlo SC Odontostomatologia II, Ospedale San Paolo  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo G.","family":"Arduino","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chirurgiche, CIR Dental School Universit\u00e0 Degli Studi di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Lampiano","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chirurgiche, CIR Dental School Universit\u00e0 Degli Studi di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0130-0799","authenticated-orcid":false,"given":"Alessio","family":"Gambino","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chirurgiche, CIR Dental School Universit\u00e0 Degli Studi di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Broccoletti","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chirurgiche, CIR Dental School Universit\u00e0 Degli Studi di Torino  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7287-2188","authenticated-orcid":false,"given":"Elena M.","family":"Varoni","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche Chirurgiche e Odontoiatriche Universit\u00e0 Degli Studi di Milano  Milan Italy"},{"name":"ASST Santi Paolo e Carlo SC Odontostomatologia II, Ospedale San Paolo  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0218-8292","authenticated-orcid":false,"given":"Giovanni","family":"Lodi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Biomediche Chirurgiche e Odontoiatriche Universit\u00e0 Degli Studi di Milano  Milan Italy"},{"name":"ASST Santi Paolo e Carlo SC Odontostomatologia II, Ospedale San Paolo  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13810"},{"key":"e_1_2_11_3_1","volume-title":"Oral Potentially Malignant Disorders \u2010 Healthcare Professional Training","author":"Albuquerque 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