{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:40:07Z","timestamp":1788907207272,"version":"build-2803163510"},"reference-count":102,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T00:00:00Z","timestamp":1719705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Head and Neck Cancer (HNC) patients receiving radiotherapy (RT) often suffer from xerostomia and\/or hyposalivation. As saliva plays an important antimicrobial and cleansing roles, these patients are at higher risks of opportunistic infections. This narrative review aims to provide an overview of current evidence on oral\n                      <jats:italic>Candida<\/jats:italic>\n                      colonisation and infection in these patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A literature review of clinical studies on oral\n                      <jats:italic>Candida<\/jats:italic>\n                      colonisation and candidiasis in HNC patients receiving radiotherapy\/chemoradiotherapy was conducted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Many clinical studies found high levels of\n                      <jats:italic>Candida<\/jats:italic>\n                      colonisation and a substantial proportion of post\u2010RT HNC patients suffering from oropharyngeal candidiasis (OPC). Importantly, oral\n                      <jats:italic>Candida<\/jats:italic>\n                      could be a reservoir for life\u2010threatening systemic infection in immunocompromised patients. The rising prevalence of non\u2010\n                      <jats:italic>albicans Candida<\/jats:italic>\n                      species and drug\u2010resistant infections has made identification of\n                      <jats:italic>Candida<\/jats:italic>\n                      species and antifungal susceptibility more important. Recent advances in oral microbiome and its interactions with\n                      <jats:italic>Candida<\/jats:italic>\n                      are discussed. This review also offers perspectives on limitations of current evidence and suggestions for future research.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Further research to better understand\n                      <jats:italic>Candida<\/jats:italic>\n                      carriage, microbiome, OPC, and xerostomia\/hyposalivation post\u2010RT would aid in devising a more comprehensive long\u2010term management plan and novel therapeutic approaches for HNC patients to achieve the full benefits of RT while minimising side effects.\n                    <\/jats:p>\n                  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