{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:23:51Z","timestamp":1762957431872,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Determine the saliva and serum levels of neopterin (NP) and 7,8\u2010dihydroneopterin (7,8NP) in periodontitis patients and to reveal the relationship of these data with clinical periodontal parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Twenty\u2010three patients with stage III\/grade B periodontitis and 23 periodontally healthy individuals were included. Clinical periodontal measurements were recorded (plaque index, pocket depth, clinical attachment loss &amp; bleeding on probing). Saliva and serum levels of NP and 7,8NP were analyzed by high\u2010performance liquid chromatography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Saliva NP, 7,8NP and Total Neopterin (TNP) levels were significantly elevated in the periodontitis than the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).ROC analyses of saliva NP, 7,8NP and TNP yielded areas under the curves of 0.873\u20130.938 for discriminating periodontitis from health, and saliva TNP was found the most accurate biomarker (AUC\u2009=\u20090.938).There was no significant difference among the periodontitis and control groups for saliva TNP\/NP and TNP\/7,8NP ratios and serum NP, 7,8NP and TNP levels (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Increased saliva TNP, NP and 7,8NP levels in periodontitis may suggest these biomarkers are regulating immune activation and oxidative stress mechanism in periodontal inflammation. Additionally, together with these results, equivalence of the TNP\/NP ratio in intergroups may suggest that the effects of immune activation and oxidative stress mechanisms are equal in the periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.15061","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T17:09:56Z","timestamp":1720199396000},"page":"949-958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neopterin, 7,8\u2010dihydroneopterin, total neopterin levels and their ratio in periodontitis: New dilemma"],"prefix":"10.1111","volume":"31","author":[{"given":"Emrah","family":"Turkmen","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadi","family":"Sayedyousef","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Istanbul Medipol University  Istanbul Turkey"},{"name":"Department of Periodontology, Institute of Health Sciences Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9505-062X","authenticated-orcid":false,"given":"Dorukhan","family":"Ucar","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Istanbul Medipol University  Istanbul Turkey"},{"name":"Department of Periodontology, Institute of Health Sciences Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3435-1856","authenticated-orcid":false,"given":"Melis","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6291-5922","authenticated-orcid":false,"given":"Nihan","family":"Akdo\u011fan","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur","family":"Balci","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eivge","family":"Kurgan","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilal","family":"Toygar","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Department of Periodontology Istanbul Medipol University  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhittin A.","family":"Serdar","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, School of Medicine Ac\u0131badem University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2012.01.016"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/pteridines-2020-0015"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.03.002"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0719"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-022-01028-5"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-016-3433-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.12.019"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2015.10.003"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox7070080"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12294"},{"issue":"12","key":"e_1_2_11_12_1","article-title":"Neopterin levels in periodontitis and after nonsurgical periodontal therapy: Evaluation of gingival Crevicular fluid, Oral fluid, serum and urinary samples\u2014A case\u2010control study","volume":"10","author":"Heneberk O.","year":"2022","journal-title":"Biomedicine"},{"issue":"5","key":"e_1_2_11_13_1","article-title":"Neopterin, the cell\u2010mediated immune response biomarker, in inflammatory periodontal diseases: A narrative review of a more than fifty years old biomarker","volume":"11","author":"Heneberk O.","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1515\/pterid-2015-0004"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.152207"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.071"},{"issue":"3","key":"e_1_2_11_17_1","first-page":"1721","article-title":"Increased neopterin concentrations in patients with cancer: Indicator of oxidative stress?","volume":"19","author":"Murr C.","year":"1999","journal-title":"Anticancer Research"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26472"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.7.720"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019\u20105278.44690"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070096"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4987.201406"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.6118\/jmm.2017.23.1.32"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1712718"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20365"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1515\/pteridines-2022-0045"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12221"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-7757-2017-0199"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(97)00154-X"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020200014"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14448"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsr.2022.10.002"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.15061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T18:36:06Z","timestamp":1745519766000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.15061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,5]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/odi.15061"],"URL":"https:\/\/doi.org\/10.1111\/odi.15061","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"type":"print","value":"1354-523X"},{"type":"electronic","value":"1601-0825"}],"subject":[],"published":{"date-parts":[[2024,7,5]]},"assertion":[{"value":"2024-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}