{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T18:51:18Z","timestamp":1772218278549,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare salivary flow rates between females and males, before and after radiation therapy (RT) for head and neck cancer (HNC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective observational multicenter cohort study (OraRad). Stimulated whole salivary flow was measured before RT and at 6 and 18\u2009months after RT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean (95% confidence interval) salivary flow in g\/min before RT was 0.81 (0.71, 0.90) in females (<jats:italic>n<\/jats:italic>\u2009=\u2009107) and 1.20 (1.15, 1.25) in males (<jats:italic>n<\/jats:italic>\u2009=\u2009391) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001); at 6\u2009months was 0.34 (0.24, 0.44) in females and 0.50 (0.44, 0.55) in males (<jats:italic>p<\/jats:italic>\u2009=\u20090.01); at 18\u2009months was 0.49 (0.38, 0.59) in females and 0.70 (0.64, 0.75) in males (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Median nadir salivary flow after RT was 0.22 in females and 0.35 in males (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). A lower nadir salivary flow in females, but not males, was associated with an increased risk for tooth failure (<jats:italic>p<\/jats:italic>\u2009=\u20090.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Females with HNC have lower stimulated whole salivary flow than males, before and after RT. Low salivary flow after RT may be a risk factor for tooth failure among females. The lower pre\u2010RT salivary flow rates in females, combined with prior literature in other populations, indicates that, in general, females have lower stimulated salivary flow than males.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.15068","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T08:48:57Z","timestamp":1721033337000},"page":"857-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Females have lower salivary flow than males, before and after radiation therapy for head\/neck cancer"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7662-6937","authenticated-orcid":false,"given":"Rajesh V.","family":"Lalla","sequence":"first","affiliation":[{"name":"Section of Oral Medicine University of Connecticut School of Dental Medicine  Farmington Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika S.","family":"Helgeson","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, School of Public Health University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Komal","family":"Virk","sequence":"additional","affiliation":[{"name":"Division of General Dentistry University of Connecticut School of Dental Medicine  Farmington Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Lu","sequence":"additional","affiliation":[{"name":"Division of Biostatistics, School of Public Health University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5596-7222","authenticated-orcid":false,"given":"Nathaniel S.","family":"Treister","sequence":"additional","affiliation":[{"name":"Division of Oral Medicine and Dentistry Brigham and Women's Hospital  Boston Massachusetts USA"},{"name":"Department of Oral Medicine, Infection and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas P.","family":"Sollecito","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine University of Pennsylvania School of Dental Medicine  Philadelphia Pennsylvania USA"},{"name":"Division of Oral Medicine University of Pennsylvania Health System  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian L.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Surgery and Bluestone Center for Clinical Research New York University College of Dentistry  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren L.","family":"Patton","sequence":"additional","affiliation":[{"name":"Division of Craniofacial and Surgical Care, Adams School of Dentistry University of North Carolina  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0638-4335","authenticated-orcid":false,"given":"Michael T.","family":"Brennan","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine\/Oral &amp; Maxillofacial Surgery Atrium Health Carolinas Medical Center  Charlotte North Carolina USA"},{"name":"Department of Otolaryngology\/Head &amp; Neck Surgery Wake Forest University School of Medicine, Medical Center Boulevard  Winston\u2010Salem North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100528.2000.280108.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010021\u201001667\u20100"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/23800844221086563"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2021.11.021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2002.0296"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803117"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3290\/j.ohpd.a39684"},{"issue":"6","key":"e_1_2_10_9_1","first-page":"227","article-title":"Secretion rate and buffer effect of resting and stimulated whole saliva as a function of age and sex","volume":"7","author":"Heintze U.","year":"1983","journal-title":"Swedish Dental Journal"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2006.06.010"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201085861\u20108"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2023.03.009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903\u2010017\u20100344\u2010y"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2016.06.040"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.105783"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010010\u20100445\u20103"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2008.0353"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2005.09.001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345810600120201"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520\u2010023\u201007750\u20102"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345940730080401"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2022.08.017"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33948"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.15068","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T18:36:25Z","timestamp":1745519785000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.15068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,15]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/odi.15068"],"URL":"https:\/\/doi.org\/10.1111\/odi.15068","archive":["Portico"],"relation":{},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,15]]},"assertion":[{"value":"2024-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}