{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:45:12Z","timestamp":1790397912475,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This case\u2013control study investigated the association\n                      <jats:bold>s<\/jats:bold>\n                      between maternal plasma vitamin B12, homocysteine, and red blood cell (RBC) folate levels and the risk of cleft lip with or without cleft palate (CL\/P) in offspring.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods<\/jats:title>\n                    <jats:p>The study compared 94 mothers and children with non\u2010syndromic CL\/P from a teaching hospital in Thailand to 94 mother\u2010infant controls from local well\u2010baby clinics, frequency\u2010matched by birth date and mother's education. Data included anthropometric measurements, blood sample analyses, and a questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) estimated the associations through multiple logistic regression, adjusting for confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mothers with higher plasma vitamin B12 levels had a lower risk of having a child with CL\/P compared to those in the lowest quartile. This association was more pronounced among mothers without a family history of orofacial clefts and those who were not underweight. Conversely, elevated homocysteine levels, a marker of impaired B vitamin metabolism, increased the risk of CL\/P. No association was found between RBC folate and CL\/P.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher maternal vitamin B12 levels are associated with a reduced risk of CL\/P, while elevated homocysteine levels may increase the risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15079","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:34:43Z","timestamp":1721694883000},"page":"565-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Maternal micronutrient biomarkers and risk of non\u2010syndromic cleft lip\/palate: A case\u2013control study"],"prefix":"10.1111","volume":"31","author":[{"given":"Araya","family":"Pisek","sequence":"first","affiliation":[{"name":"Division of Dental Public Health, Department of Preventive Dentistry, Faculty of Dentistry Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christy M.","family":"McKinney","sequence":"additional","affiliation":[{"name":"Division of Craniofacial Medicine, Department of Pediatrics University of Washington, and Seattle Children's Research Institute  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benja","family":"Muktabhant","sequence":"additional","affiliation":[{"name":"Department of Public Health Administration, Health Promotion and Nutrition, Faculty of Public Health Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6628-0306","authenticated-orcid":false,"given":"Waranuch","family":"Pitiphat","sequence":"additional","affiliation":[{"name":"Division of Dental Public Health, Department of Preventive Dentistry, Faculty of Dentistry Khon Kaen University  Khon Kaen Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14146"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm\u20102014\u20100784"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.206599"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43042\u2010020\u201000108\u2010x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12292"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2016.06.011"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20740"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12050609"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043383692"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.781333"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.013441"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11901\u2010006\u20100019\u20107"},{"key":"e_1_2_11_14_1","unstructured":"Centers for Disease Control and Prevention. (2010).National birth defects preventive study.https:\/\/www.cdc.gov\/ncbddd\/birthdefects\/nbdps\u2010public\u2010access\u2010procedures.html"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp025"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010animal\u2010020518\u2010115206"},{"key":"e_1_2_11_17_1","volume-title":"Household food insecurity access scale (HFIAS) for measurement of food access: Indicator guide version 3","author":"Coates J.","year":"2007"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114514002906"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1597\/05\u2010167"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.111.000992"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277\u20109536(99)00314\u20107"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1192"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.802285"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665620987677"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1830"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.40"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14174"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648\u2010199103000\u201000008"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051283"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/scs.0000000000004488"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.9.1349"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1290\/1543\u2010706x(2003)039<0098:hoaaap>2.0.co;2"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496471"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1597\/06\u2010151.1"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.2176"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513507452"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23505"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(09)60695\u20104"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/1055665621998394"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20037"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20762"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.identj.2024.02.005"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13963"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.26.15227"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.242628"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/15648265080292s110"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408363.2021.1885339"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/oso\/9780195139068.003.0002"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13880"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/meg.0000000000001014"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.5.1449S"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20179"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20348"},{"issue":"6","key":"e_1_2_11_54_1","first-page":"1246","article-title":"Detection of Helicobacter pylori and virulence\u2010associated genes in saliva samples of asymptomatic persons in Northeast Thailand","volume":"47","author":"Tirapattanun A.","year":"2016","journal-title":"The Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/19424396.2006.12222253"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2018.05.004"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1067\/s0002\u20109378(03)00592\u20101"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(03)15268\u20103"},{"key":"e_1_2_11_59_1","volume-title":"Guideline: Optimal serum and red blood cell folate concentrations in women of reproductive age for prevention of neural tube defects","author":"World Health Organization","year":"2015"},{"key":"e_1_2_11_60_1","volume-title":"Serum and red blood cell folate concentrations for assessing folate status in populations","author":"World Health Organization","year":"2015"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20103016.2012.01291.x"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.013243"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1597\/09\u2010156"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1827"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.15079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T03:19:08Z","timestamp":1744082348000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.15079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,22]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1111\/odi.15079"],"URL":"https:\/\/doi.org\/10.1111\/odi.15079","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ODI.15079\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15079\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15079\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15079\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15079\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15079\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15079\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,22]]},"assertion":[{"value":"2024-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}