{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T05:11:07Z","timestamp":1781932267445,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Periodontitis is a common oral disease that is aggravated by occlusal trauma. Fibrin is a protein that participates in blood clotting and is involved in several human diseases. The deposition of fibrin in periodontal tissues can induce periodontitis, while mechanical forces may regulate the degradation of fibrin. Our study investigated how occlusal trauma aggravating periodontitis through regulating the plasminogen\/plasmin system and fibrin deposition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This study included 84 C57BL\/6 mice in which periodontitis was induced with or without occlusal trauma. Micro\u2010computed tomography was used to assess bone resorption. Fibrin, fibrinogen, plasminogen, plasmin, tissue plasminogen activator (t\u2010PA), and urokinase plasminogen activator (u\u2010PA) levels were measured using Frazer\u2013Lendrum staining, quantitative reverse transcription polymerase chain reaction, enzyme\u2010linked immunosorbent assay, western blotting, immunofluorescence staining, and immunohistochemistry staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Occlusal trauma aggravated inflammation and bone resorption. The periodontitis group showed significant fibrin deposition. Occlusal trauma increased fibrin deposition and neutrophil aggregation. The periodontitis with occlusal trauma group had decreased fibrinogen, t\u2010PA, and u\u2010PA expression and plasmin and fibrin degradation product levels, as well as increased plasminogen levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Occlusal trauma promotes excessive fibrin deposition by suppressing the plasminogen\/plasmin system, thus exacerbating periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.15081","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T05:05:24Z","timestamp":1721711124000},"page":"959-969","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Occlusal trauma aggravates periodontitis through the plasminogen\/plasmin system"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8559-591X","authenticated-orcid":false,"given":"Xinran","family":"Liu","sequence":"first","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology Sichuan University  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Li","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology Sichuan University  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5305-6639","authenticated-orcid":false,"given":"Jinle","family":"Li","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, Department of General Clinic, West China Hospital of Stomatology Sichuan University  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianqi","family":"Wang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology Sichuan University  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ding","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology Sichuan University  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3076-4971","authenticated-orcid":false,"given":"Yuan","family":"Yue","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology Sichuan University  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology Sichuan University  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wei","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, Department of Oral Implantology, West China Hospital of Stomatology Sichuan University  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7207-9131","authenticated-orcid":false,"given":"Liang","family":"Hao","sequence":"additional","affiliation":[{"name":"The State Key Laboratory of Oral Diseases &amp; National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology Sichuan University  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2023.2197779"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2013.05.002"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13081838"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2013.1654"},{"key":"e_1_2_11_6_1","first-page":"4667","article-title":"The plasminogen activation system in inflammation","volume":"13","author":"Del R. 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