{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:51:06Z","timestamp":1780919466342,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,18]],"date-time":"2024-08-18T00:00:00Z","timestamp":1723939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis aimed to compare the risk of recurrence and cancer progression after surgical treatment for oral potentially malignant disorders (OPMD) and precancerous lesions in different anatomical sites.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A comprehensive search was conducted in nine databases and grey literature. We included randomized controlled trials assessing surgical treatment efficacy for OPMD and precancerous lesions of cervical, vaginal, anal, and penile sites. Excision or ablation surgical treatments were considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 12 studies met the eligibility criteria for oral leukoplakia (OL), proliferative verrucous leukoplakia, cervical intraepithelial neoplasia (CIN), vaginal intraepithelial neoplasia, and anal intraepithelial neoplasia (AIN). In qualitative analysis of surgical protocols, the lack of margin description impacts the clinical outcomes of OL and AIN, and the ablative protocols were heterogeneous in both OPMD and precancerous lesions. No significant difference in OL (risk ratio 0.82 [95% CI: 0.59\u20131.15]) and CIN (risk ratio 0.31 [95% CI: 0.09\u20131.09]) for recurrence was observed when cold\u2010knife was compared with ablative protocols. OL exhibited higher recurrence and cancer progression rates compared to CIN and AIN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is no difference in recurrence risk post\u2010surgical treatment for OL and CIN. Surgical protocols for oral leukoplakia and CIN\/AIN lack standardized approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15098","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T01:19:47Z","timestamp":1724030387000},"page":"89-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Surgical protocols for oral leukoplakia and precancerous lesions across three different anatomic sites"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7504-7597","authenticated-orcid":false,"given":"Caique Mariano","family":"Pedroso","sequence":"first","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School State University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2088-1912","authenticated-orcid":false,"given":"Erison Santana","family":"do Santos","sequence":"additional","affiliation":[{"name":"Oral Diagnosis Department, Piracicaba Dental School State University of Campinas  Piracicaba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3372-1536","authenticated-orcid":false,"given":"F\u00e1bio Abreu","family":"Alves","sequence":"additional","affiliation":[{"name":"Department of Stomatology, School of Dentistry University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"},{"name":"Department of Stomatology A.C. 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