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Next, a calcium ion\u2010chelating agent (BAPTA\u2010AM) was applied to detect the suppression of intracellular calcium overload in macrophage pyroptosis. Then, network pharmacology, western blot (WB) analysis, and Fluo\u20104 calcium assay were conducted to explore the role of GRb1 on intracellular calcium overload. To gain a better understanding of GRb1 in calcium overload\u2010induced macrophage pyroptosis linked AP, GRb1\u2010treated AP models were established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We discovered clinically and experimentally that calcium overload\u2010dependent macrophage pyroptosis is involved in AP pathogenesis, and reducing calcium overload greatly decreased macrophage pyroptosis in an AP cell model. Next, based on GRb1's inhibitory role in aberrant intracellular calcium accumulation, we discovered that GRb1 alleviates AP by suppressing calcium\u2010dependent macrophage pyroptosis in both in\u00a0vitro and in\u00a0vivo models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GRb1 is an effective therapeutic strategy to rescue the periapical tissues from inflammation due to its anti\u2010pyroptosis function. Thus, the present study supports further investigation of GRb1 as an adjuvant therapy for AP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/odi.15103","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T05:00:19Z","timestamp":1724043619000},"page":"541-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ginsenoside Rb1 ameliorates apical periodontitis via suppressing macrophage pyroptosis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0280-3774","authenticated-orcid":false,"given":"Xiaoyue","family":"Guan","sequence":"first","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology Xi'an Jiaotong University  Xi'an China"},{"name":"Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology Xi'an Jiaotong University  Xi'an 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