{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:53:56Z","timestamp":1772160836495,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Toll\u2010like receptor (TLR)\u20109, may play a role in periodontal disease inflammation. This study measured TLR\u20109 and its related molecules, absence in melanoma\u20102 (AIM\u20102) and Z\u2010DNA\u2010binding protein\u20101 (ZBP\u20101), in gingival crevicular fluid (GCF) from patients with varying stages of periodontal disease to assess the role of pathogen\u2010derived nucleic acids in inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The study comprised 80 participants: 20 with Stage III Grade C periodontitis, 20 with Stage III Grade B periodontitis (P\u2010Stage III\u2010B), 19 with gingivitis, and 21 with periodontal health. Parameters including probing depth (PD), clinical attachment level (CAL), plaque index (PI), and bleeding on probing (BOP) were recorded. ELISA was used to analyze TLR\u20109, AIM\u20102, and ZBP\u20101 levels in GCF. Nonparametric tests were used for statistical comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The total amount of TLR\u20109 was higher in P\u2010Stage III\u2010B than in the healthy group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Similarly, the gingivitis group exhibited elevated GCF TLR\u20109 levels compared to the healthy group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). GCF AIM\u20102 and ZBP\u20101 levels remained consistent across groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Significant correlations were found between GCF TLR\u20109 and CAL (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), BOP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), PI (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), and GCF volume (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggested that the TLR\u20109\u2010mediated inflammatory process plays a role in periodontal disease, as evidenced by the increased levels of TLR\u20109 in GCF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15108","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T15:24:23Z","timestamp":1724340263000},"page":"941-948","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gingival crevicular fluid levels of\n                    <scp>TLR<\/scp>\n                    \u20109,\n                    <scp>AIM<\/scp>\n                    \u20102, and\n                    <scp>ZBP<\/scp>\n                    \u20101 in periodontal diseases"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3631-3933","authenticated-orcid":false,"given":"B\u00fc\u015fra","family":"Y\u0131lmaz","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dentistry Ege University  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclnur","family":"Emingil","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry Ege University  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veli \u00d6zgen","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry Ayd\u0131n Adnan Menderes University  Ayd\u0131n Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harika","family":"Atmaca","sequence":"additional","affiliation":[{"name":"Department of Biology, School of Science Celal Bayar University  Manisa Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timur","family":"K\u00f6se","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Medical Informatics Ege University School of Medicine  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2679-9100","authenticated-orcid":false,"given":"Alpdo\u011fan","family":"Kantarc\u0131","sequence":"additional","affiliation":[{"name":"The Forsyth Institute  Cambridge Massachusetts USA"},{"name":"Department of Oral Medicine, Infection and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2005.00669.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.19\u20100222"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.23\u20100184"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2023.105640"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u2010302X.2008.00448.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2011.04.002"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12595"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12002"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/8757233"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515609062"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511761676"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2013.09.001"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514526240"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2009.01523.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u2010302X.2007.00377.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.05.006"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00424\u201015"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.38"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010021\u201003875\u20108"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13268"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970\u20109290.159134"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12618"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202376"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.160553"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00046\u201008"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.6.555"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010immunol\u2010101320"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3203"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100765.2011.01405.x"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100757.2009.00327.x"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2011.110522"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.120739"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2041\u20101014.2009.00551.x"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkac044"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201848070"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/NRDP.2017.69"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06013"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051X.2010.01534.x"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18\u20100006"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13104"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001268"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201087016\u20101"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.03.002"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120362"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3MR1220\u2010748RRRRR"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.856118"}],"container-title":["Oral Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/odi.15108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T14:36:10Z","timestamp":1745505370000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/odi.15108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/odi.15108"],"URL":"https:\/\/doi.org\/10.1111\/odi.15108","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/ODI.15108\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15108\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15108\/v2\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15108\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15108\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15108\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15108\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15108\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/ODI.15108\/v2\/decision1","asserted-by":"object"}]},"ISSN":["1354-523X","1601-0825"],"issn-type":[{"value":"1354-523X","type":"print"},{"value":"1601-0825","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,22]]},"assertion":[{"value":"2024-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}