{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T03:04:50Z","timestamp":1782788690429,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Proliferative verrucous leukoplakia (PVL) is an oral potentially malignant disorder. Forms that affect only one tissue are poorly studied, especially the exclusively gingival PVL (gPVL), which may have a more increased malignant transformation potential. The aim of the present study was to characterise the gPVL and its risk of malignant transformation to better raise awareness of this specific disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>The systematic review was performed on PubMed, Scopus, Web of Science and Google Scholar. Only articles reporting primary studies, case reports and case series were included. The meta\u2010analysis was performed for the cancer prevalence, proportion of smokers, age and sex ratio, recurrences of gPVL and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1298 studies were assessed for eligibility by reading titles and abstracts. Fourteen original articles were included with a total of 58 patients. The malignant transformation rate of gPVL was 47.75%. The mortality was 5.84%. The mean follow\u2010up duration before malignant transformation was 3\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>gPVL seems to have a faster malignant transformation rate than the other forms of PVL. Finding anatomo\u2010pathological or genetic markers could be a line of research to predict gPVL malignant transformation and improve its diagnosis and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15142","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T10:15:35Z","timestamp":1728555335000},"page":"50-58","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Gingival Proliferative Verrucous Leukoplakia and Cancer: A Systematic Review With Meta\u2010Analysis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3828-1365","authenticated-orcid":false,"given":"Valentin","family":"Vergier","sequence":"first","affiliation":[{"name":"Department of Odontology, Health Faculty Universit\u00e9 Paris Cit\u00e9  Montrouge France"},{"name":"Oral and Buccal Medicine Department Charles Foix Hospital, AP\u2010HP  Ivry\u2010sur\u2010Seine France"},{"name":"Laboratory Orofacial Pathologies, Imaging, and Biotherapies (BRIO) (2496) Universit\u00e9 Paris Cit\u00e9  Montrouge France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Lu\u00eds","family":"Porporatti","sequence":"additional","affiliation":[{"name":"Laboratory of Orofacial Neurobiology (7543) Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Babajko","sequence":"additional","affiliation":[{"name":"Laboratory Orofacial Pathologies, Imaging, and Biotherapies (BRIO) (2496) Universit\u00e9 Paris Cit\u00e9  Montrouge France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihs\u00e8ne","family":"Taihi","sequence":"additional","affiliation":[{"name":"Department of Odontology, Health Faculty Universit\u00e9 Paris Cit\u00e9  Montrouge France"},{"name":"Laboratory Orofacial Pathologies, Imaging, and Biotherapies (BRIO) (2496) Universit\u00e9 Paris Cit\u00e9  Montrouge France"},{"name":"Oral Surgery Department Rothschild Hospital, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2023.152104"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010022\u201001021\u2010x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fander.2021.06.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14171"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/moe.2000.108950"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13194843"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_189_17"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20104220(85)90313\u20105"},{"issue":"3","key":"e_1_2_10_10_1","first-page":"205","article-title":"Proliferative Verrucous Gingival Leukoplakia: A Sinister Condition","volume":"3","author":"Hayes M.","year":"2006","journal-title":"Periodontal Practice Today"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u2010051x.1987.tb01515.x"},{"key":"e_1_2_10_12_1","unstructured":"Higgins J. P. T. andS.Green.2011.Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. Cochrane Collaboration.http:\/\/handbook.cochrane.org\/."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030\u20104220(94)90040\u2010x"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5785060"},{"issue":"1","key":"e_1_2_10_15_1","first-page":"25","article-title":"Proliferative Verrucous Leukoplakia: Rapid Progression From Mild Dysplasia to Verrucous Carcinoma\u2014A Report of a Case and Review of Literature","volume":"3","author":"Mahajan M. 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