{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:23:06Z","timestamp":1791616986228,"version":"4.3.4"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T00:00:00Z","timestamp":1728259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyze the characteristics of a series of oral reactions to injectable soft tissue fillers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Cases diagnosed as oral reactions to injectable soft tissue fillers were selected from eight Pathology laboratories. Information was retrieved from the laboratory charts and from the review of the hematoxylin and eosin\u2010stained histological slides.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 151 patients showed a mean age of 54.9\u2009years, and 136 (90.1%) were females. Mean time of onset was 20.4\u2009months, and the lips were the most frequent location (72.8%). Most cases presented as asymptomatic isolated nodules, with a mean size of 17.4\u2009mm. Silicone (38.5%), polymethylmetacrylate (33%), and hyaluronic acid (11.9%) were the three most common fillers. Granulomas, foamy macrophages, and multinucleated giant cells were observed in 44%, 51.5%, and 65.3% of the cases, respectively. Time of onset was shorter for males (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.033), and symptoms were common in the upper lip, buccal mucosa, and lower vestibule (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010). Foamy macrophages were more common in association with silicone and collagen (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), whereas multinucleated giant cells were more common in association with polymethylmetacrylate, hydroxiapatite, and polylactic acid (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Clinicians should consider reactions to injectable soft tissue fillers when evaluating asymptomatic submucosal nodules affecting the lips of adult\/older females.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15143","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:25:32Z","timestamp":1728347132000},"page":"899-910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Oral\/Perioral Reactions to Injectable Soft Tissue Fillers: A Clinicopathological Multicentric Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0317-8878","authenticated-orcid":false,"given":"F\u00e1bio Ramoa","family":"Pires","sequence":"first","affiliation":[{"name":"Oral Pathology, School of Dentistry, Rio de Janeiro State University, and Post Graduation Program in Dentistry Est\u00e1cio de S\u00e1 University  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lio Marcos Tsutyia","family":"Said","sequence":"additional","affiliation":[{"name":"Post Graduation Program in Dentistry Est\u00e1cio de 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