{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:19Z","timestamp":1787015899797,"version":"build-2736575974"},"reference-count":61,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Fungiform papillae enlargement is a common oral manifestation of neurofibromatosis type 1 (NF1). This study aimed to objectively evaluate the size, number, and symmetry of fungiform papillae in NF1 individuals and investigate the relationship between these alterations and taste perception, salivary flow, dietary habits, and BMI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional case\u2013control study was conducted on 80 participants (40 with NF1 and 40 controls), matched by age and sex. Participants underwent quantitative and morphological evaluation of fungiform papillae, gustatory perception tests, sialometry, saliva analysis, xerostomia assessment, dietary assessments, and Body Mass Index calculations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The NF1 group exhibited significantly larger and more asymmetric fungiform papillae and exhibited a higher detection threshold for sweet and sour tastes, as well as hyposalivation and lower preference for healthy foods compared to the controls. No correlation was found between papillae morphology, gustatory perception tests, saliva properties, xerostomia, food preferences, or BMI in the NF1 group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Enlarged and asymmetric fungiform papillae, hyposalivation, heightened sensitivity to sweet and sour tastes, and reduced healthy eating habits were common in NF1. Although fungiform papillae alterations seem unrelated to taste sensitivity and food preferences, further investigation is needed to better understand the mechanisms underlying these changes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15148","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T02:13:54Z","timestamp":1728958434000},"page":"656-671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fungiform Papillae and Gustatory Function in Neurofibromatosis Type 1: A Case\u2013Control Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5301-6001","authenticated-orcid":false,"given":"Flavia","family":"Kleinsorgen","sequence":"first","affiliation":[{"name":"Graduate Program in Pathology, School of Medicine Universidade Federal Fluminense  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6720-3636","authenticated-orcid":false,"given":"Elo\u00e1 Borges","family":"Luna","sequence":"additional","affiliation":[{"name":"Graduate Program in Pathology, School of Medicine Universidade Federal Fluminense  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2408-1856","authenticated-orcid":false,"given":"P\u00e2mella","family":"de Pinho Montovani","sequence":"additional","affiliation":[{"name":"Graduate Program in Pathology, School of Medicine Universidade Federal Fluminense  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4501-1857","authenticated-orcid":false,"given":"Analucia Rampazzo","family":"Xavier","sequence":"additional","affiliation":[{"name":"Graduate Program in Pathology, School of Medicine Universidade Federal Fluminense  Niter\u00f3i Rio de Janeiro Brazil"},{"name":"Department of Pathology, School of Medicine Universidade Federal Fluminense  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5983-0840","authenticated-orcid":false,"given":"Alexandra Anastacio Monteiro","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Universidade Federal Fluminense  Niter\u00f3i Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-0507","authenticated-orcid":false,"given":"Rafaela Elvira","family":"Rozza\u2010de\u2010Menezes","sequence":"additional","affiliation":[{"name":"Graduate Program in Pathology, School of Medicine Universidade Federal Fluminense  Niter\u00f3i Rio de Janeiro Brazil"},{"name":"Department of Pathology, School of Medicine Universidade Federal Fluminense  Niter\u00f3i Rio de Janeiro Brazil"},{"name":"Neurofibromatosis National Center (Centro Nacional De Neurofibromatose, CNNF)  Rio De Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5647-282X","authenticated-orcid":false,"given":"Karin Soares","family":"Cunha","sequence":"additional","affiliation":[{"name":"Graduate Program in Pathology, School of Medicine Universidade Federal Fluminense  Niter\u00f3i Rio de Janeiro Brazil"},{"name":"Department of Pathology, School of Medicine Universidade Federal Fluminense  Niter\u00f3i Rio de Janeiro Brazil"},{"name":"Neurofibromatosis National Center (Centro Nacional De Neurofibromatose, CNNF)  Rio De Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-014-1298-y"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001205"},{"key":"e_1_2_11_4_1","unstructured":"Arguelhes B. 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