{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:49:43Z","timestamp":1791654583585,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PRIN202254FLSB"],"award-info":[{"award-number":["PRIN202254FLSB"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the impact of fluocinonide 0.05% gel formulation for the topical treatment of oral lichen planus (OLP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Through an RCT design, 47 patients with OLP were randomly allocated for topical OLP treatment with fluocinonide 0.05% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923) or placebo (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924). Patients were examined for OLP symptoms, signs, disease severity, and extension score changes over 6\u2010month follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 6\u2009months, in comparison with placebo, patients treated with fluocinonide experienced a significant reduction of OLP symptoms (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.024), signs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014), and OLP extension score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028). The two\u2010way ANOVA estimation models revealed that treatment with fluocinonide determined, at 6\u2009months, a positive significant effect on the reduced OLP signs (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017), OLP symptoms (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026), and OLP extension score (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.028). The multivariate regression analysis highlighted that anxiety, stress, and depression were significant predictors of every analyzed OLP outcome (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05 for each parameter) and that patients who had baseline anxiety, depression, and stress gained more benefits from fluocinonide at 6\u2010month follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Topical fluocinonide 0.05% was more efficacious compared to placebo in reducing OLP outcomes at 6\u2010month follow\u2010up. Anxiety, depression, and stress were significant predictors of OLP outcomes and positively impacted the treatment with fluocinonide at 6\u2009months.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15156","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T02:23:41Z","timestamp":1728959021000},"page":"510-521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Impact of Topical Fluocinonide on Oral Lichen Planus Evolution: Randomized Controlled Clinical Trial"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6717-8899","authenticated-orcid":false,"given":"Alessandro","family":"Polizzi","sequence":"first","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties, School of Dentistry University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca Martino","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences University of Milan  Milan Italy"},{"name":"Fondazione Ca'Granda IRCCS Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Santonocito","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties, School of Dentistry University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Alibrandi","sequence":"additional","affiliation":[{"name":"Department of Economics, Unit of Statistical and Mathematical Sciences University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Elisa","family":"Verz\u00ec","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties, Unit of Dermatology University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Isola","sequence":"additional","affiliation":[{"name":"Department of General Surgery and Surgical\u2010Medical Specialties, School of Dentistry University of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12821"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12128"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14398"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13270"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(00)80012-8"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2008.00688.x"},{"issue":"3","key":"e_1_2_10_8_1","first-page":"61","article-title":"The Topical Treatment of Atrophic\u2010Erosive Oral Lichen Planus With Fluocinonide in a Bioadhesive Gel, Chlorhexidine and Miconazole Gel. 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