{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:58:19Z","timestamp":1793228299038,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81802696"],"award-info":[{"award-number":["81802696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                      (\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      ) is a keystone periodontal pathogen associated with various gastro\u2010intestinal tract cancers. However, whether\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      can promote oral squamous cell carcinoma (OSCC) and the underlying mechanism associated with such promotion remain unclear.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In this study, OSCC xenograft models were used to evaluate the effects of\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      on tumor progression. The functional studies were done on several OSCC cell lines in\u00a0vitro.\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      \u2010specific 16S rRNA fluorescent in\u00a0situ hybridization (FISH) was used to test its prevalence in clinical samples.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found that\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      increased tumor volume and tumor growth in OSCC nude models. Functional studies demonstrated that\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      inhibited the apoptosis of OSCC cells by promoting cellular autophagy.\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      was more prevalent in FISH samples from patients with OSCC than from patients with leukoplakia or healthy subjects (70% vs. 47.2% vs. 33.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These data suggest that\n                      <jats:italic>P. gingivalis<\/jats:italic>\n                      plays an accelerating role in OSCC progression and contributes to OSCC by enhancing the autophagy pathway to reduce carcinoma apoptosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15157","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T05:35:03Z","timestamp":1729575303000},"page":"492-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["<i>Porphyromonas gingivalis<\/i>\n                    Promotes Oral Squamous Cell Carcinoma Progression by Modulating Autophagy"],"prefix":"10.1111","volume":"31","author":[{"given":"Keyong","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Endodontics, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology &amp; Shanghai Research Institute of Stomatology  Shanghai 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