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This study aims to evaluate the immunoexpression of p300, H2AacK5, and H3AcK27 in samples of ameloblastoma (AMB) (<jats:italic>n<\/jats:italic>\u2009=\u200930), odontogenic keratocyst (OK) (<jats:italic>n<\/jats:italic>\u2009=\u200915), adenomatoid odontogenic tumor (AOT) (<jats:italic>n<\/jats:italic>\u2009=\u200910), odontogenic fibroma (OF) (<jats:italic>n<\/jats:italic>\u2009=\u20098), calcifying odontogenic cyst (COC) (<jats:italic>n<\/jats:italic>\u2009=\u20098), odontogenic myxoma (MIX) (<jats:italic>n<\/jats:italic>\u2009=\u200910), and ameloblastic fibroma (AF) (<jats:italic>n<\/jats:italic>\u2009=\u200906). The percentage of p300\u2010positive cells was higher in AOT and decreased in COC, OK, AMB, AF, OF, and MIX. H2AacK5\u2010positive cells were higher in AF and decreased in AOT, COC, OK, OF, AMB, and MIX, whereas H3acK27\u2010positive cells were higher in AOT and decreased in COC, OK, AF, OF, AMB, and MIX. The expression of these proteins was higher in nonaggressive lesions in comparison to aggressive lesions. There was a positive correlation between p300 and H2AacK5, and H3acK27 in AMB, MIX, and OF, whereas there was a positive correlation between p300 and H2AacK5 in AOT and COC. The histone acetylation may be involved in the biological behavior of these lesions, which could be used to improve their diagnosis and treatment.<\/jats:p>","DOI":"10.1111\/odi.15164","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T09:46:37Z","timestamp":1729590397000},"page":"555-564","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunohistochemical Evaluation of p300, H2AacK5 and H3AcK27 in Odontogenic Cysts and Tumors"],"prefix":"10.1111","volume":"31","author":[{"given":"Luciane De Jesus","family":"Carvalho","sequence":"first","affiliation":[{"name":"Laboratory of Pathological Anatomy and Immunohistochemistry, School of Dentistry Federal University of Par\u00e1  Bel\u00e9m Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7856-1324","authenticated-orcid":false,"given":"Douglas 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