{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:33:39Z","timestamp":1788554019882,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Hormone replacement therapy (HRT) is a commonly used strategy for treating menopausal symptoms, while its relation with periodontitis remains unclear. This study aimed to explore the potential effects of HRT on periodontitis, mainly in aspects of bone loss and inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The alveolar bone height (ABH), alveolar bone thickness (ABT), and bone mineral density (BMD) were measured in menopausal women with periodontitis who had received HRT or had not received HRT by cone beam computed tomography. Based on a rat model of periodontitis, the alveolar bone loss was evaluated by micro\u2010computed tomography and bone\u2010related biochemical markers. The expression\/levels of inflammatory markers were measured to reflect periodontal inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Although the differences were not all significant in each premolars\/molars, the mesial\/distal ABH and buccal\/lingual ABT were lower, and the mesial\/distal BMD was higher in patients in the HRT group than those in the control group. In a rat model of periodontitis, the alveolar bone loss was relieved by HRT. Additionally, HRT significantly weakened the elevation of inflammatory markers, including TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106 in periodontitis rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HRT contributes to the remission of periodontitis by inhibiting alveolar bone loss and inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15192","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T07:09:36Z","timestamp":1730876976000},"page":"1307-1316","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hormone Replacement Therapy Relieves Periodontitis by Inhibiting Alveolar Bone Loss and Inflammation"],"prefix":"10.1111","volume":"31","author":[{"given":"Ying","family":"Man","sequence":"first","affiliation":[{"name":"Department of Stomatology Shengli Oilfield Central Hospital  Dongying China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyong","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Stomatology Shengli Oilfield Central Hospital  Dongying China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Stomatology Shengli Oilfield Central Hospital  Dongying China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Shengli Oilfield Central Hospital  Dongying China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Stomatology Shengli Oilfield Central Hospital  Dongying China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3881-7353","authenticated-orcid":false,"given":"Shengjie","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Stomatology Shengli Oilfield Central Hospital  Dongying China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpbs.jpbs_145_21"},{"issue":"10","key":"e_1_2_9_3_1","first-page":"1048","article-title":"Progesterone Modulates Cadmium\u2010Induced Oxidative Stress and Inflammation in Hepatic Tissues of Wistar Rats","volume":"14","author":"Alese M. 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