{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:09:26Z","timestamp":1792069766748,"version":"4.4.0"},"reference-count":76,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Medication\u2010related osteonecrosis of the jaw (MRONJ) is a rare but debilitating disease characterized by a progressive necrosis of jaw bones in patients who have received anti\u2010resorptive or anti\u2010angiogenic therapies. Unfortunately, we still have no validated preventive or pharmaceutical interventions to help these patients, primarily due to our limited understanding of MRONJ pathogenesis. Here, we offer an extensive review of recent studies relevant to MRONJ pathogenesis. We present a hypothesis regarding the coupling of bone resorption and angiogenesis that relies on osteoblast\u2010derived, matrix\u2010bound vascular endothelial growth factors to explain why ONJ is associated with both anti\u2010resorptive and anti\u2010angiogenic agents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A narrative review was conducted by searching databases, including PubMed, Scopus, Google Scholar, and Web of Science, to retrieve relevant reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Reduced bone resorption leads to reduced angiogenesis, and vice versa, creating a vicious cycle that ultimately results in ischemic necrosis of the jaw. Additionally, we suggest that reduced angiogenesis, induced by anti\u2010resorptive or anti\u2010angiogenic agents, aggravates bacterial infection\u2010induced bone necrosis, explaining why the jaw bone is particularly susceptible to necrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our novel hypothesis will facilitate the advancement of future research and the development of more targeted approaches to managing MRONJ.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15198","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T05:45:27Z","timestamp":1731908727000},"page":"1073-1083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Mechanisms Underlying Medication\u2010Related Osteonecrosis of the Jaw"],"prefix":"10.1111","volume":"31","author":[{"given":"Kyeongho","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Oral Histology and Developmental Biology, School of Dentistry and Dental Research Institute Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kihun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, School of Medicine Pusan National University  Yangsan Korea"},{"name":"Department of Anatomy, School of Medicine Pusan National University  Yangsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral Histology and Developmental Biology, School of Dentistry and Dental Research Institute Seoul National University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1672-5730","authenticated-orcid":false,"given":"Jin\u2010Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Research Institute for Intractable Osteonecrosis of the Jaw, College of Medicine Ewha Womans University  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Hoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Changwon Gyeongsang National University Hospital, Gyeongsang National University School of Medicine  Jinju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9796-8266","authenticated-orcid":false,"given":"Yun Hak","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics, School of Medicine Pusan National University  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