{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T19:14:25Z","timestamp":1777144465480,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate serum, placental levels of active\u2010matrix metalloproteinase\u20108 (aMMP\u20108), myeloperoxidase (MPO) in preterm\u2010birth with\/without pre\u2010eclampsia and term counterparts in relation with clinical periodontal parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical periodontal measurements were recorded. Serum and placenta samples were collected during 173 full\u2010term (FT), pre\u2010term (PT) or pre\u2010term complicated by pre\u2010eclampsia (PTPE) deliveries. aMMP\u20108 levels were measured by IFMA. MPO levels in the serum and placenta samples were determined by ELISA. Data were tested using non\u2010parametric tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PTBE group exhibited higher full\u2010mouth probing depth and clinical attachment loss values than the other two groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Percentages of sites with plaque and bleeding on probing were lower in the PTBE group than in\u2009the other groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Serum aMMP\u20108 and MPO concentrations were higher in PTPE group than in\u2009the other groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Placenta aMMP\u20108 level was higher in the control group than in\u2009the PTPE group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). There was no significant difference between the groups in the placenta MPO levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Within the limits of this cross\u2010sectional study, it may be suggested that serum aMMP\u20108 and MPO concentrations together with placenta aMMP\u20108 levels may be associated with and reflect adverse pregnancy outcomes. Clinical periodontal findings did not reveal significant associations with these proteolytic and oxidative biomarkers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/odi.15202","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T00:34:33Z","timestamp":1731630873000},"page":"1333-1341","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Active\u2010Matrix Metalloproteinase\u20108, Myeloperoxidase in Relation With Periodontics, Preterm Birth"],"prefix":"10.1111","volume":"31","author":[{"given":"Murat","family":"Alan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Izmir Tepecik Training and Research Hospital  Izmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Sorsa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Diseases University of Helsinki  Helsinki 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