{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:54:19Z","timestamp":1772160859017,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oral Diseases"],"published-print":{"date-parts":[[2025,4]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n Craniofacial and oral malformations (COMs) represent an important class of human developmental disorders with profound implications on the anatomical structure, appearance, and various physiological functions. In this study, we aimed to define the spectrum of COMs and analysis its features or possible influencing factors to improve the surveillance and control of the disease.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n We organized a multicenter survey of COMs from 19 hospitals in 14 provinces. The clinical data of COM cases were collected from the electronic medical records system, cleaned and aggregated for analysis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 90,895 COM cases with 76 types of diseases were identified from 34,649,545 hospital population. The four most common COMs were supernumery teeth (62.64%), cleft lip and palate (28.53%), microdontia (2.86%), and tooth agenesis (1.70%). The remaining 72 diseases were detected in 3881 cases and were considered to be rare COMs. Moreover, 84.72% of rare COMs also manifested as other malformations or dysfunctions of the bone, skin and other tissues.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n COMs exhibit age and gender distribution patterns, have multiple types, and significant dental malformations. The diagnostic criteria and registration practices for COMs influence their reported prevalence and temporal trends, necessitating future improvements.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/odi.15207","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T06:40:25Z","timestamp":1732689625000},"page":"1245-1254","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Spectrum of Craniofacial and Oral Malformations in China, a Multicenter Study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6747-1734","authenticated-orcid":false,"given":"Xiaohong","family":"Duan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology & Clinic of Oral Rare Diseases and Genetic Diseases, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3432-4807","authenticated-orcid":false,"given":"Yulong","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology & Clinic of Oral Rare Diseases and Genetic Diseases, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuguo","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices Peking University School and Hospital of Stomatology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0747-7381","authenticated-orcid":false,"given":"Yaling","family":"Song","sequence":"additional","affiliation":[{"name":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology Wuhan University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Nanjing Stomatological Hospital, Medical School of Nanjing University Nanjing Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University Zhengzhou 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Stomatological Hospital of Tianjin Medical University Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology, the General Hospital of Ningxia Medical University Ningxia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liling","family":"Ren","sequence":"additional","affiliation":[{"name":"Stomatology School Lanzhou University Lanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endodontics Stomatology Hospital, Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7022-3897","authenticated-orcid":false,"given":"Weihong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Affiliated Stomatological Hospital of Kunming Medical University Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengbin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, School and Hospital of Stomatology Wenzhou Medical University Wenzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinggao","family":"Song","sequence":"additional","affiliation":[{"name":"Hospital of Stomatology Zunyi Medical University Zunyi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baisheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Hunan Xiangya Stomatological Hospital Central South University Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Stomatology Medical College of Dalian University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Li","sequence":"additional","affiliation":[{"name":"Affiliated Stomatology Hospital of Guangzhou Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Yinchuan Hospital of Stomatology Yinchuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2497-1165","authenticated-orcid":false,"given":"Yanli","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology & Clinic of Oral Rare Diseases and Genetic Diseases, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4151-1678","authenticated-orcid":false,"given":"Xinyue","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology & Clinic of Oral Rare Diseases and Genetic Diseases, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3452-3005","authenticated-orcid":false,"given":"Wenyan","family":"Ruan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology & Clinic of Oral Rare Diseases and Genetic Diseases, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology & Clinic of Oral Rare Diseases and Genetic Diseases, School of Stomatology The Fourth Military Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongcheng","family":"Gong","sequence":"additional","affiliation":[{"name":"Oncological Department of Oral and Maxillofacial Surgery The First Affiliated Hospital of Xinjiang Medical University, School\/Hospital of Stomatology 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Stomatology Inner Mongolia People's Hospital Hohhot China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4412-7498","authenticated-orcid":false,"given":"Zhexuan","family":"Bao","sequence":"additional","affiliation":[{"name":"Shanxi Provincial People's Hospital Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Li","sequence":"additional","affiliation":[{"name":"Hanzhong Stomatology Hospital Hanzhong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"213","article-title":"Craniofacial and Oral Malformations in an Autopsy Population of Japanese Human Fetuses and Newborns","volume":"2","author":"Akimoto 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